Neurotransmitters |
selectivity (Ki nm) |
receptor |
what's will happened if |
|
expression pattrenn |
endogenous |
exogenous |
agonized/enhanced |
|
antagonized/inhibited |
|
from wikipedia otherwise specified
Top expressed in: |
serotonin |
https://en.wikipedia.org/wiki/Serotonin
/ |
|
SERT |
Serotonin reduction |
|
increase serotonin |
https://watermark.silverchair.com/7-4-431.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAl0wggJZBgkqhkiG9w0BBwagggJKMIICRgIBADCCAj8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMhZ9AYpwW_aLxO8jUAgEQgIICENGNUKGcVAv3kyvEQ6j1fWo-e5VMr4DvIREwOlRoOfcq-0sA2VDH6fAPNCAHbZi_YAorxmboHSSZoyUW1uDkrCvvFioTBrETckPsr3wNzKJTBdL-yCLPQaZDeu9GYgZ83rGszWgKmgeP0sKjJmx5toTg4CNJEf5RdL-sCKTflH7qjnYER0rCWVJoJP3MOhKOqrtHxxGgrAJJG-UYnRMWjNSapFS41bB4BQIiiogV9ON0hUu20sS_5EuhVyMujVQbukhIsZtGquNY_g1oIiunrF0opBNPt99zaKzV_MBdk5sj0JVynAleKyCcIUOvN8eZNNrgR2A-QIO9JQkYHW6QD8nyIURKDhw0rj6_URc_B4QcxB7CjD8V-C6NLjVW9USUmoElPW9FpOumfrJ127-2W1ZA0LO8vJXXedOxcqtcokiwfRFFlT09xzqZ2D-UKrk3RkTqnjkiGK12nUSoJDNLW_WGEPCsYp4C_t65GvZSVYABqn42mgQgN6W3CRpvKcNhE29l7UcVP33_rWIgM-UF08XpUWNHboaS80w0eUE0FGQTvbLJebgANdWD7IzSQnHREyzZqPGZBLNXnz1-jdg9jYLfvZwxSD9su5pjZylhV_6k5vglQ4B307nP4fwouufDvMMaajWkN3Vnw7bGAt4ostQcDCEe9XmlvTnUqzqMSxuurcTC0rIzgFGmJLqzieD-Gw
decrease D2 sensivity in striatal |
(sexual dysfunction, decrease drug seeking behaviors, anti gambling, anti Eating disorders, Akathisia , effect of ssris) which is known opposite effect of Dopamine 3 overactivity
https://www.psychiatrist.com/JCP/article/Pages/double-blind-placebo-controlled-study-efficacy-safety-paroxetine-pathological-gambling.aspx
https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor
https://en.wikipedia.org/wiki/Akathisia
https://en.wikipedia.org/wiki/Impulse-control_disorder
added to that empathy and restless leg syndrome of dopamine 3 blocking
downregulate dopamine 3 receptors |
|
|
https://en.wikipedia.org/wiki/Serotonin
1 |
HT1A |
https://en.wikipedia.org/wiki/Oxytocin
and my exp
increase ability to enjoy: love, empathy, talking and connection to others, bonding, trust, understanded, cuteness (there relation with oxytocin) |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/figure/f1/
https://en.wikipedia.org/wiki/5-HT_receptor
negative feedback |
https://en.wikipedia.org/wiki/5-HT_receptor
Antidepressants (post-synaptic receptor agonists and pre-synaptic autoreceptor antagonists serve as antidepressants |
|
https://en.wikipedia.org/wiki/5-HT_receptor
depressant |
https://pubmed.ncbi.nlm.nih.gov/7905292/
reversed the sexual side effects of SSRIs |
|
https://en.wikipedia.org/wiki/Serotonin
1.36 |
HT1B |
https://www.ncbi.nlm.nih.gov/pubmed/26423528
http://grantome.com/grant/NIH/R21-MH090555-02
induced repetitive behavior of ocd |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/figure/f1/
https://en.wikipedia.org/wiki/5-HT_receptor
negative feedback |
|
https://en.wikipedia.org/wiki/Serotonin
aggression |
https://en.wikipedia.org/wiki/Isamoltane
https://en.wikipedia.org/wiki/AR-A000002
https://en.wikipedia.org/wiki/SB-216641
anxiolytic |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2
https://pubmed.ncbi.nlm.nih.gov/25892302/
impulsivity and drug addiction (by increasing dopamine levels and dopamine release in the nucleus accumbens the place most expressed D3 receptors) |
|
https://en.wikipedia.org/wiki/Serotonin
1.59 |
HT1D |
https://en.wikipedia.org/wiki/SB-699551
https://en.wikipedia.org/wiki/5-HT_receptor
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3
negative feedback |
https://en.wikipedia.org/wiki/Serotonin
Vasoconstriction |
https://en.wikipedia.org/wiki/BRL-15572
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1565844/
inhibit/modulating release of glutamate |
|
https://www.ncbi.nlm.nih.gov/pubmed/11313163
http://grantome.com/grant/NIH/R21-MH090555-02
antidepressant |
https://en.wikipedia.org/wiki/5-HT1D_receptor
affects locomotion and anxiety |
"inhibits both dural vasodilation and inflammation"
https://www.guidetopharmacology.org/GRAC/DatabaseSearchForward?searchString=HT1D&searchCategories=all&species=none&type=all&comments=includeComments&order=rank&submit=Search+Database
inflammation |
|
https://en.wikipedia.org/wiki/Serotonin
2.38 |
HT1E |
https://en.wikipedia.org/wiki/5-HT1E_receptor
no info in the first 100 Google search result included
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=4
2020/12/18
might involved in the regulation of memory in humans |
|
https://en.wikipedia.org/wiki/Serotonin
2.56 |
HT7 |
https://en.wikipedia.org/wiki/5-HT_receptor
Autoreceptor |
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/ (external links used)
https://en.wikipedia.org/wiki/Serotonin
https://www.ncbi.nlm.nih.gov/pubmed/17869441
https://www.ncbi.nlm.nih.gov/pubmed/15755477
antidepressant & Cognition & ability to recognize old objects |
|
>>https://en.wikipedia.org/wiki/Serotonin
the main endogenous legend of 5-HT receptors, is a functionally selective agonist at this receptor, activating phospholipase C (which leads to inositol triphosphate accumulation), but does not activate phospholipase A2, which would result in arachidonic acid signaling
>>https://en.wikipedia.org/wiki/Functional_selectivity
2.58 |
HT2C |
https://en.wikipedia.org/wiki/5-HT2C_receptor
increase of corticotrophin releasing hormone (CRH) and vasopressin mRNA in the paraventricular nucleus and proopiomelanocortin in the anterior pituitary lobe. In rats |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/
https://www.ncbi.nlm.nih.gov/pubmed/27241709
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/
decrease impulsivity and motivation for drug and food |
https://en.wikipedia.org/wiki/5-HT2C_receptor
https://en.wikipedia.org/wiki/PNU-22394
reduced cognitive deficits |
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/
anxiety:
https://en.wikipedia.org/wiki/PNU-181731
anxiolytic or sometimes in some aspect anxiety |
https://en.wikipedia.org/wiki/5-HT2C_receptor
estradiol and progesterone decrease the receptor concentration in the ventral hippocampus |
https://en.wikipedia.org/wiki/Atypical_antipsychotic
increases release serotonin, norepinephrine and dopamine |
|
https://en.wikipedia.org/wiki/Serotonin
2.75 |
HT2B |
https://en.wikipedia.org/wiki/Serotonin
empathy |
https://en.wikipedia.org/wiki/5-HT2B_receptor
Autoreceptor |
https://www.ncbi.nlm.nih.gov/pubmed/22158014
https://www.ncbi.nlm.nih.gov/pubmed/26727039
Required for behavioral effects of SSRIs |
https://en.wikipedia.org/wiki/Serotonin
pulmonary hypertension |
|
|
|
https://en.wikipedia.org/wiki/Serotonin
3.15 |
HT1F |
https://en.wikipedia.org/wiki/LY334370
treatment of migraine headaches |
https://en.wikipedia.org/wiki/LY334370
development was halted due to toxicity |
|
|
https://en.wikipedia.org/wiki/Serotonin
the main endogenous ligand of 5-HT receptors, is a functionally selective agonist at this receptor, activating phospholipase C (which leads to inositol triphosphate accumulation), but does not activate phospholipase A2, which would result in arachidonic acid signalling
>>https://en.wikipedia.org/wiki/Functional_selectivity
3.64 |
HT2A |
https://en.wikipedia.org/wiki/Lysergic_acid_diethylamide
hallucination |
https://en.wikipedia.org/wiki/5-HT2A_receptor
anti-inflammatory |
inhibition:
https://en.wikipedia.org/wiki/Atypical_antipsychotic
promotion:
https://en.wikipedia.org/wiki/5-HT2A_receptor
inhibit dopamine release and increases in hormonal levels of oxytocin, prolactin, ACTH, corticosterone, and renin |
antidepressant |
https://en.wikipedia.org/wiki/Serotonin_syndrome
Serotonin syndrome |
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC446220/
antidepressant |
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064746/
5-HT2AR-mGluR2 complex is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists |
|
https://en.wikipedia.org/wiki/Serotonin
31 |
HT6 |
https://en.wikipedia.org/wiki/Serotonin
https://en.wikipedia.org/wiki/WAY-208466
anti-anxiety |
https://www.ncbi.nlm.nih.gov/pubmed/20217056
https://en.wikipedia.org/wiki/Serotonin
https://www.ncbi.nlm.nih.gov/pubmed/17428998
antidepressant |
https://www.ncbi.nlm.nih.gov/pubmed/17625499
increase GABA |
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/
Antagonists enhance cognitive performance; blockade of signaling is anxiogenic |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706851/
https://www.ncbi.nlm.nih.gov/pubmed/16005519
reverse a scopolamine-induced cognitive deficit but it appears that 5-HT6 receptor blockade is more consistently effective in alleviating memory deficits than increasing memory in normally functioning animals |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706851/
Alzheimer's disease |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/
block effect of ssris |
|
https://en.wikipedia.org/wiki/Serotonin
39.7 |
Author:
HT4 |
https://en.wikipedia.org/wiki/Serotonin
https://en.wikipedia.org/wiki/BIMU8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/
Memory & learning + antidepressant effects |
https://ar.wikipedia.org/wiki/%D8%B3%D9%8A%D8%B3%D8%A7%D8%A8%D8%B1%D9%8A%D8%AF
increase acetylcholine |
|
https://en.wikipedia.org/wiki/GR-113808
respiratory depression |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=11
Modulation of dopaminergic neurotransmission. |
|
https://en.wikipedia.org/wiki/Serotonin
79.2 |
HT5A |
https://en.wikipedia.org/wiki/Serotonin
https://en.wikipedia.org/wiki/5-HT_receptor
Auto receptor + Memory consolidation |
|
https://en.wikipedia.org/wiki/Valerian_(herb)
implicated in the sleep-wake cycle |
|
https://en.wikipedia.org/wiki/Serotonin
187.1 |
HT3 |
Serotonin syndrome |
|
https://en.wikipedia.org/wiki/Ondansetron
Anti-vomiting |
https://en.wikipedia.org/wiki/Serotonin
https://en.wikipedia.org/wiki/5-HT3_receptor
anxiolysis |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/
antidepressant |
|
as of pspp ki database the dopamine affinity to its receptors is:
DOPAMINE D4 0.999999969
DOPAMINE D3 9.677419355
Dopamine Transporter 10.80645161
DOPAMINE D4.4 11.61290323
DOPAMINE D1 20.96774194
DOPAMINE D2 Long 25.96774194
Dopamine D1A 35.48387097
DOPAMINE D5 36.77419355
Adrenergic Alpha 39.51612903
DOPAMINE D4.2 47.25806452
Norepinephrine transporter 52.09677419
DOPAMINE D2 59.19354839
TA1 68.06451613
5-HT1A 87.90322581
5-HT7 87.90322581
dopamine |
http://drugcentral.org/drugcard/947?q=Dopamine
Wikipedia
/ |
|
DAT |
dopamine reduction |
|
increase dopamine |
|
http://drugcentral.org/drugcard/947?q=Dopamine
Wikipedia
1 |
found associations of ADHD
----------
associated with dyskinesia
>>https://parkinsonsnewstoday.com/dopamine-agonists/
D1 |
https://en.wikipedia.org/wiki/Methylphenidate
in prefrontal cortex : cognition-enhancing effects |
https://www.quora.com/Can-selective-full-dopamine-D1-agonists-like-Dihydrexidine-be-used-to-treat-ADHD
hypotension |
https://www.quora.com/Can-selective-full-dopamine-D1-agonists-like-Dihydrexidine-be-used-to-treat-ADHD
D1 receptors in the 'direct pathway' provide a range of possible decisions derived from activity in the cortex |
https://en.wikipedia.org/wiki/Ecopipam
https://en.wikipedia.org/wiki/A-77636
https://en.wikipedia.org/wiki/Dopamine_receptor_D1
rewarded behaviors and pleasure, One such behavior is eating + nootropic, anorectic, rewarding and profound antiparkinson effects |
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(09)01476-0/pdf#pageBody
https://academic.oup.com/ijnp/article/23/5/287/5735643
goal directed behaviors (motivation) |
|
https://en.wikipedia.org/wiki/Ecopipam
anxiety and depression |
https://en.wikipedia.org/wiki/Dopamine_receptor_D1
effective antagonist d1(mostly the cause)/d5 product inhibition of acute euphoric effects of cocaine |
https://en.wikipedia.org/wiki/Ecopipam
treatment of Tourette's syndrome |
|
http://drugcentral.org/drugcard/947?q=Dopamine
Wikipedia
1 |
The finding that the metabotropic glutamate receptor 2/3 (mGlu2/3) metabotropic glutamate receptor agonist, LY404039, improves clinical symptoms in schizophrenia (Patil et al., 2007) has stimulated a greater interest in the putative interactions between mGlu2/3 receptors and dopamine D2 receptors. A study using mGlu2 and mGlu3 receptor knockout mice has demonstrated that the proportion of D2 receptors in the striata is elevated by 220% and that there is a 67-fold and 17-fold increase in the sensitivity to a D2 agonist
>>https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/metabotropic-glutamate-receptor-2
D2 |
https://www.quora.com/Can-selective-full-dopamine-D1-agonists-like-Dihydrexidine-be-used-to-treat-ADHD
"increasing memory for complex tasks" >> https://en.wikipedia.org/wiki/Neuronal_calcium_sensor-1
D2 receptors in the 'indirect pathway' are activated to filter and select one of decisions provided by D1 receptor, add to that increase reward for complex stuff like: internet, , programming, biohacking, high degree in sience and high ability to understand and use it, big dreams , urge/enjoyment to complete tasks perfectly (over activation if together with anxiety cause ocd) etc.. |
|
https://ar.wikipedia.org/wiki/%D9%85%D9%8A%D8%AA%D9%88%D9%83%D9%84%D9%88%D8%A8%D8%B1%D8%A7%D9%85%D9%8A%D8%AF
Anti-vomiting |
https://en.wikipedia.org/wiki/Neuroleptic_malignant_syndrome
Neuroleptic malignant syndrome |
https://en.wikipedia.org/wiki/Amisulpride
antipsychotic positive symptoms |
"Pellegrino et al. and Franckx and Noel also reported domperidone-induced extrapyramidal symptoms especially dystonia"
https://mansapublishers.com/IJCH/article/download/2331/1885/4876
extrapyramidal symptoms especially dystonia |
|
hyperactivity and racing thought of adhd |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839459/
induce locomotion activity |
https://en.wikipedia.org/wiki/Dopamine_agonist
"D2 receptor knockout mice exhibit hyperprolactinemia." https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=215
reduce prolactin |
increase capability to feel interested |
|
|
|
D2s |
https://www.sciencedirect.com/topics/neuroscience/dopamine-autoreceptor
negative feedback: reduce dopamine release and increase dopamine reuptake |
|
|
http://drugcentral.org/drugcard/947?q=Dopamine
Wikipedia
1 |
there an interact btw serotonin and D2 and D3
high serotonin inhibit them
how D2, D3 inhibit serotonin
why?
SSRIs side effect: RLS, decrease sex, anti-ocd
is known effect of blocking D2 and D3.
D3 |
https://en.wikipedia.org/wiki/Ropinirole
https://en.wikipedia.org/wiki/Pramipexole
https://www.patientslikeme.com/treatment/5794-requip-xl-side-effects-and-efficacy?page=2#
https://www.drugs.com/comments/cabergoline/for-hyperprolactinemia.html
increase reward for: shopping, gambling, eating, drug seeking behaviors, Risk-Taking , impulsivity |
reward/urge to do recreactional activity |
https://en.wikipedia.org/wiki/Ropinirole
https://en.wikipedia.org/wiki/Pramipexole
anti-restless leg syndrome |
https://en.wikipedia.org/wiki/Dopamine_agonist
reduce prolactin |
|
https://ar.wikipedia.org/wiki/%D9%85%D9%8A%D8%AA%D9%88%D9%83%D9%84%D9%88%D8%A8%D8%B1%D8%A7%D9%85%D9%8A%D8%AF
Anti-vomiting |
analyzed after seeing many interactions and lastly by this source
https://en.wikipedia.org/wiki/Perphenazine
block agitation induced by of D3 agonizing |
my expirience with halopiridol 8mg which is selective dopamine 3 antagonist and risporidone 12mg that cause clinicaly relevent antagonisting activity at dopamine 3 because its metabolism but after days of taking it and olanzpine 15mg which is selective at dopamine 2 and 3 and other dopamine receptors
uncontrollable eye movement it like torture |
my experience with haloperidol (selective)
respiridon (non selective)(high dose)
fear from risk-taking stations |
|
https://www.vox.com/2014/10/20/6995011/addiction-dopamine-agonist-parkinsons
poriomania (A morbid impulse to wander or journey away from home.) |
increase enargy |
https://www.vox.com/2014/10/20/6995011/addiction-dopamine-agonist-parkinsons
https://en.wikipedia.org/wiki/Impulse-control_disorder
kleptomania (a recurrent urge to steal, typically without regard for need or profit.) |
increase capability to feel excited |
https://en.wikipedia.org/wiki/Impulse-control_disorder
https://en.wikipedia.org/wiki/Dopamine_agonist
Intermittent explosive disorder or IED is a clinical condition of experiencing recurrent aggressive episodes that are out of proportion of any given stressor. |
|
as for partial agonists it's from bluelight but i forgot the actual link this link about abilify increase reward for sex
https://www.bluelight.org/xf/threads/porn-addiction.908070/
abilify which is partial agonist cause risk avoidance and in the same time increase reward for sex |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=216
https://www.nature.com/articles/npp2012171.pdf?origin=ppub
https://en.wikipedia.org/wiki/SB-277,011-A
Blockade of the D3 receptor disrupts drug-associated cue-induced craving and stress-induced craving. |
my exp with multiple D3 antagonists
longer attention span (solve short attention , D3 seems have great role in this) |
|
https://www.vox.com/2014/10/20/6995011/addiction-dopamine-agonist-parkinsons
increase libido and induce sexual fantasies |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=216
Stimulation of yawning |
tested by me in this drugs:
halopiridol
respiridon
olanzpine
anti-empathy effect |
https://en.wikipedia.org/wiki/Impulse-control_disorder
https://en.wikipedia.org/wiki/Dopamine_agonist
Pyromania: is characterized by impulsive and repetitive urges to deliberately start fires. |
|
|
http://drugcentral.org/drugcard/947?q=Dopamine
Wikipedia
1 |
found associations of ADHD
no info in Wikipedia and very hard to get info in other source
poorly understood
D4 |
https://en.wikipedia.org/wiki/Dopamine_receptor_D4
https://en.wikipedia.org/wiki/Novelty_seeking
Novelty seeking (increases the propensity for exploring to select a novel choice over familiar one (eg, human example in this is relationship cheating)) |
https://en.wikipedia.org/wiki/Dopamine_receptor_D4
increase working memory performance and fear |
"Craving novelty is definitely a thing we struggle with."
https://www.reddit.com/r/ADHD/comments/qu43tc/comment/hkobqdu/?utm_source=reddit&utm_medium=web2x&context=3
"The harder I try to fall asleep the more impossible it becomes though lol
Another issue I failed to mention is that this also includes relationships… before long they feel too routine and stale and I end it abruptly. Same with work too actually, I’ve quit a few jobs on a whim because I couldn’t stand the idea of doing it for one more day, not because I hated the job, but the whole routine of it."
https://www.reddit.com/r/ADHD/comments/qu43tc/comment/hko6k7b/?utm_source=reddit&utm_medium=web2x&context=3
"Yes! It's almost like self sabotage. I hate routine with a passion."
https://www.reddit.com/r/ADHD/comments/qu43tc/comment/hknx593/?utm_source=reddit&utm_medium=web2x&context=3
they thinking to switch routines
"But then you switch it up, every x days starts a different routine."
https://www.reddit.com/r/ADHD/comments/qu43tc/comment/hkoppxe/?utm_source=reddit&utm_medium=web2x&context=3
other argeement available in that (used) post in reddit.
less productive by uability to stay i the same routien, this make you uable to stay in routine of work, because of novility seeking. |
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00231
D4Rs expressed in PFC and hippocampus affect attention, exploratory behavior, (3) and performance in novel object recognition (4,5) and inhibitory avoidance (6) cognitive tasks |
|
https://en.wikipedia.org/wiki/Dopamine_receptor_D4
https://pubmed.ncbi.nlm.nih.gov/10989267/
reverse stress-induced working memory deficits |
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994774/
https://www.longecity.org/forum/topic/100673-dopamine-agonists-pramipexolecabergoline-for-trdanhedonia/
https://www.bionews.org.uk/page_92722
associated with cheating, like in sex relationships and might other type of cheating too.. |
|
|
|
D4.7 |
https://en.wikipedia.org/wiki/Dopamine_receptor
better cognitive performance |
|
https://www.entrepreneur.com/living/there-is-a-wanderlust-gene-but-you-can-be-a-digital-nomad/311322
cause a strong desire, if not impulse, to wander, travel and explore the world.
|
|
|
|
novelty seeking is wide rang of behavior characterized by curiosity, adventure, exploration urges, backed by their rewards which is mediated by dope 4 receptors |
|
|
was no info in
>>http://drugcentral.org/drugcard/947?q=Dopamine
>>Wikipedia
but now without links i forget some info about it being x10 of D1
x10 of D1 |
found associations of ADHD
----------
associated with dyskinesia
>>https://parkinsonsnewstoday.com/dopamine-agonists/
D5 |
https://en.wikipedia.org/wiki/Brain-derived_neurotrophic_factor
Activation of Dopamine receptor D5 promotes expression of BDNF in prefrontal cortex neurons |
|
https://en.wikipedia.org/wiki/Dopamine_receptor_D5
reduces burst firing and improve motor deficits, increased motor response to administration of methamphetamine |
https://en.wikipedia.org/wiki/Dopamine_receptor_D5
learning problems (fear memory aid by B2 and M1 receptors) that may be associated with ADHD |
https://en.wikipedia.org/wiki/Dopamine_receptor_D5
hypertension |
|
going away from sad behaviors
Noradrenaline |
http://drugcentral.org/drugcard/1960
/ |
|
NET |
noradrenalin reduction |
|
increase noradrenalin |
|
http://drugcentral.org/drugcard/1960
/ |
α1 |
https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor
vasoconstriction |
https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor
anorexia |
https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor
inhibit hearing system |
|
https://en.wikipedia.org/wiki/Antihypertensive_drug
https://en.wikipedia.org/wiki/Alpha_blocker
https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor
orthostatic hypotension |
https://en.wikipedia.org/wiki/Silodosin
inhibit ejaculation but not orgasm |
|
http://drugcentral.org/drugcard/1960
1.2409381663113 |
α1A |
https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor
inhibit olfactory system |
|
|
http://drugcentral.org/drugcard/1960
1 |
α1B |
no info in Wikipedia |
|
|
http://drugcentral.org/drugcard/1960
/ |
α1C |
|
|
http://drugcentral.org/drugcard/1960
1.57782515991471 |
α1D |
|
|
http://drugcentral.org/drugcard/1960
/ |
α2 |
https://en.wikipedia.org/wiki/Alpha_blocker
vasoconstriction |
https://en.wikipedia.org/wiki/Clonidine
anti ptsd + anxiety disorders |
|
|
|
http://drugcentral.org/drugcard/1960
1.53091684434968 |
α2A |
https://en.wikipedia.org/wiki/Guanfacine
https://en.wikipedia.org/wiki/Antihypertensive_drug
https://en.wikipedia.org/wiki/Clonidine
https://en.wikipedia.org/wiki/Methylphenidate
in prefrontal cortex : cognition-enhancing effects + lowering blood pressure |
https://en.wikipedia.org/wiki/Alpha-2C_adrenergic_receptor
negative feedback: at high stimulation frequencies |
|
|
http://drugcentral.org/drugcard/1960
1.3816631130064 |
α2B |
https://en.wikipedia.org/wiki/Alpha-2B_adrenergic_receptor
emotional memory focus more on negative aspects of a situation |
|
|
http://drugcentral.org/drugcard/1960
1.53518123667377 |
α2C |
https://en.wikipedia.org/wiki/Alpha-2C_adrenergic_receptor
negative feedback : at lower levels of nerve activity |
|
|
http://drugcentral.org/drugcard/1960
1.28 |
β1 |
https://en.wikipedia.org/wiki/Beta-1_adrenergic_receptor
https://en.wikipedia.org/wiki/Metoprolol
anxiolytic |
https://en.wikipedia.org/wiki/Denopamine
https://en.wikipedia.org/wiki/Dobutamine
https://en.wikipedia.org/wiki/Xamoterol
https://en.wikipedia.org/wiki/Metoprolol
treatment of slow heart rate |
https://en.wikipedia.org/wiki/Autoreceptor
in (SNS) positive feedback |
|
https://academic.oup.com/sleep/article/44/Supplement_2/A154/6260529
https://www.malacards.org/card/short_sleep_familial_natural_2
https://pubmed.ncbi.nlm.nih.gov/31473062
https://pubmed.ncbi.nlm.nih.gov/10335905/
https://you.com/search?q=give me detailed report about ADRB1 receptors effect on sleep&tbm=youchat&cfr=chat
.then(more in depth)
.then(can you give me all source links for this info)
[1] https://news.uchicago.edu/story/gene-causes-people-sleep-less-six-and-half-hours-night [2] https://www.sleepfoundation.org/sleep-news/new-short-sleep-gene-discovered [3] https://www.huffpost.com/entry/sleep-genes-the-key-to-getting-the-best-sleep-possible_l_5d6f04b6e4b0f8b6c2d6de0e [4] https://www.sleep.org/articles/natural-short-sleepers/ [5] https://www.nih.gov/news-events/news-releases/mutation-1-adrenergic-receptor-affects-sleepwake-behaviors [6] https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRB1 [7] https://www.fda.gov/home [8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905629/ [9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449478/ [10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795613/
Short sleeper syndrome (short sleep familial natural 2)
highly expressed in the dorsal pons and that these ADRB1+ neurons are active during rapid eye movement (REM) sleep causing wakefullness
decrease melatonin release
mutatuion = higher levels of alertness during wakefulness greater sensitivity to cold temperatures (which may explain why natural short sleepers (NSS) need less sleep than the average person) have been found to accumulate more sleep pressure, likely due to their shorter sleep in the dark phase (ibti consilation= melatonin inhibition) |
|
|
https://en.wikipedia.org/wiki/Betaxolol
https://en.wikipedia.org/wiki/Bisoprolol
https://en.wikipedia.org/wiki/Norepinephrine
https://en.wikipedia.org/wiki/Nebivolol
treatment of hypertension and glaucoma |
https://en.wikipedia.org/wiki/Nebivolol
bronchoconstriction (less affective then β2) |
https://en.wikipedia.org/wiki/Nebivolol
selectively block β1 adrenergic receptors reduced typical beta-blocker-related side effects, such as fatigue, clinical depression, bradycardia, or impotence |
|
http://drugcentral.org/drugcard/1960
1.14712153518124 |
β2 |
https://en.wikipedia.org/wiki/Adrenergic_receptor
increase rewards for: fighting, listening rap music, social dominance |
https://www.nature.com/articles/npp2016238
edition:
β-AR activation increases the expression of the a-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor subunit GluA1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086548/
NE also increases memory consolidation through an increase in glucose availability
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086548/
The mRNA levels for GLUT3, a glucose transporter expressed in the central nervous system, were significantly reduced in the amygdala, but not in the hippocampus of the β3-ARKO animals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086548/
increased breakdown of glycogen by phosphorylase glycogen brain (PYGB) activation in response to β2-AR activation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086548/
while β3-AR mediates the glucose uptake by the glucose transporter type 3 (GLUT3).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086548/
βARs modulates aversive memory formation following PTC (Pavlovian threat [fear] conditioning) by initiates the activation of two plasticity-related targets: AMPA receptors (AMPARs) for associations memory acquisition to short-term memory and extracellular regulated kinase (ERK) for consolidating the learned association into a long-term memory
|
|
https://en.wikipedia.org/wiki/Atenolol
depression |
https://en.wikipedia.org/wiki/Nebivolol
bronchoconstriction |
|
my experience with terbutaline
nervous and excitable, increase respiration speed, fine visual Hallucinations, rather not to say empathy talk |
|
|
http://drugcentral.org/drugcard/1960
1.14498933901919 |
β3 |
https://en.wikipedia.org/wiki/Adrenergic_receptor
tremors |
https://en.wikipedia.org/wiki/Amibegron
antidepressant and anxiolytic |
|
|
|
https://en.wikipedia.org/wiki/Mirabegron
https://en.wikipedia.org/wiki/Solabegron
https://en.wikipedia.org/wiki/Vibegron
treat overactive bladder |
https://en.wikipedia.org/wiki/Beta-3_adrenergic_receptor
https://examine.com/supplements/oleoylethanolamide/research/#Yl1DjJP-neurology_Yl1DjJP-miscellaneous-mechanisms
induce fat breaking in adipose tissue / anti muscle stress effects
encourages a reduction in food intake |
|
|
|
histamine |
PSPP
102.92 |
|
H1 |
https://pubmed.ncbi.nlm.nih.gov/18845973/
orthostatic hypotension |
https://en.wikipedia.org/wiki/Histamine
Sleep-wake cycle (promotes wakefulness), body temperature, nociception, endocrine homeostasis, regulates appetite, involved in cognition |
|
https://en.wikipedia.org/wiki/Antihistamine
anti-sensitivity |
https://en.wikipedia.org/wiki/Antihistamine
anti-insomnia |
https://en.wikipedia.org/wiki/Antihistamine
anti-acne |
dizziness |
|
you.com
Tuberomammillary_nucleus, Pars_reticulata |
PSPP
15.848931924611 |
H2 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698467/
https://link.springer.com/article/10.1007/BF00432550
promote aggression |
|
https://en.wikipedia.org/wiki/Antihistamine
The ulcer |
https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.20015#:~:text=studies%2C%20histamine%20and%20stimulation%20of,effects%20of%20histamine%20on%20waking.
stimulation of the histamine H1 receptor (H1R) or blockade of the histamine H2 receptor (H2R) increase measures of anxiety |
https://www.scielo.br/j/bjmbr/a/pgwjTqDJmsqG8c7TVbbrpQR/?format=pdf&lang=en
impairment of memory consolidation |
|
PSPP
6.78 |
H3 |
https://en.wikipedia.org/wiki/Histamine_H3_receptor
autoreceptors |
|
https://en.wikipedia.org/wiki/Betahistine
anti-vertigo |
https://en.wikipedia.org/wiki/Betahistine
increase histamine, acetylcholine, norepinephrine, serotonin, GABA release |
https://en.wikipedia.org/wiki/Ciproxifan
stimulant + wakefulness + cognitive enhancing at relatively low levels of receptor occupancy |
https://en.wikipedia.org/wiki/Thioperamide
improve memory consolidation |
|
|
|
side effects include difficulty sleeping, nausea, and feeling worried
treatment of excessive daytime sleepiness in adults with narcolepsy.[2] It is a histamine 3 (H3) receptor antagonist/inverse agonist
>>https://en.m.wikipedia.org/wiki/Pitolisant
>>my exp with betahistine he was diminishing the uncaring of lamotrigine
Histamine H1 receptor antagonists and H3 receptor agonists decrease the anxiety state
https://pubmed.ncbi.nlm.nih.gov/10917464/
more avidance of awakeing based anxiety
https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.20015#:~:text=studies%2C%20histamine%20and%20stimulation%20of,effects%20of%20histamine%20on%20waking.
increase wakefulness and partially cognition by increasing ability to feeling worried, personally i called it awwerness, seems more accurate word |
|
PSPP
17.1 |
H4 |
|
|
https://en.wikipedia.org/wiki/Histamine_H4_receptor
https://en.wikipedia.org/wiki/JNJ-7777120
https://en.wikipedia.org/wiki/VUF-6002
anti-inflammatory and antihyperalgesic effects |
|
in kidatabase used:
HUMAN
Chick
RAT
acetylcholine |
Muscarinic |
|
|
asyt T |
|
|
increase acetylcholine |
|
|
1 |
M1 |
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1
https://en.wikipedia.org/wiki/Hyoscine
Secretion from salivary glands |
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1
aggression |
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1
https://en.wikipedia.org/wiki/Telenzepine
Secretion from salivary glands |
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1
https://en.wikipedia.org/wiki/Pirenzepine
Gastric acid secretion from stomach and muscle spasm. |
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1
olfactory behaviors (e.g. mating is the pairing of either opposite-sex or hermaphroditic organisms ) |
|
https://en.wikipedia.org/wiki/Hyoscine
inhibit ability of recall memory |
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1
Delirium hallucinations |
agonisting cause anxiety-like behaviour
>https://pubmed.ncbi.nlm.nih.gov/11374337/
anxiolytic |
|
|
>>https://pubmed.ncbi.nlm.nih.gov/11374337/
disrupt spontaneous working memory |
|
|
100.882352941176 |
M2 |
https://en.wikipedia.org/wiki/Autoreceptor
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M4
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M2
negative feedback |
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M2
slow the heart rate |
|
https://en.wikipedia.org/wiki/Methoctramine
Responsible for decrease in sexual activity, as a study using rats confirmed |
|
|
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M2
Mediating olfactory guided behaviors (e.g. odor discrimination, aggression, mating).[10] |
|
235.294117647059 |
M5 |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=17
Stimulation of gastric acid secretion. |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=17
increase dopamine release |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=17
M5 receptor knockout mice exhibit a reduction in the reinforcing effects and withdrawal symptoms of cocaine and morphine |
|
corpus callosum, substantia nigra, hypothalamus, inferior ganglion of vagus nerve, placenta, prefrontal cortex, right lobe of liver, pharynx, Brodmann area 9, hippocampus proper |
|
M4 |
https://en.wikipedia.org/wiki/Clozapine
hypersalivation |
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M4
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor
inhibit D1-induced locomotion stimulation |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=16
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369681/
Inhibition of dopaminergic (D1 receptor) signaling |
https://en.wikipedia.org/wiki/Autoreceptor
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M4
negative feedback |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=16
treatment of Parkinson's disease |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=16
knockout mice exhibit an increase in anxiolysis compared to wild-type mice |
|
|
M3 |
https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M3
increased secretions from stomach (emesis) |
|
https://en.wikipedia.org/wiki/Pimozide
change glucose to weight gain (olanzpine)+diabetes side-effects |
https://en.wikipedia.org/wiki/Darifenacin
decreases the urgency to urinate |
https://www.atsjournals.org/doi/full/10.1513/pats.200504-038SR
anti-asthma |
|
nicotinic |
|
|
α1 |
no info in the first 100 Google search result |
|
α2 |
http://learnmem.cshlp.org/content/24/6/231.full
https://en.wikipedia.org/wiki/CHRNA2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831006/
influence hippocampus-dependent learning and memory and behaviors |
|
α3 |
|
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=464&familyId=76&familyType=IC
Heterozygous α3 mice are less sensitive to nicotine-induced seizures. |
|
α4 |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=465&familyId=76&familyType=IC
induced release of dopamine |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=465&familyId=76&familyType=IC
more sensitive to nicotine-induced hypothermia and nicotine-induced seizures and sleep disruptions |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=465&familyId=76&familyType=IC
altered nicotinic modulation of respiratory rhythm |
|
α5 |
|
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=466&familyId=76&familyType=IC
Knockout mice show increased nicotine intake in self-administration tests, Reduced sensitivity to nicotine-induced behavioral effects and seizures, Increased attentional performance |
|
22.35 |
7,75 (nicotine) |
α6 |
https://www.ncbi.nlm.nih.gov/pubmed/23594044
https://en.wikipedia.org/wiki/CHRNA6
increase reward and reinforcing effects |
|
|
|
|
103 (nicotine) |
α7 |
https://en.wikipedia.org/wiki/Nicotinic_acetylcholine_receptor
some of the cognitive effects of nicotine |
|
|
|
|
α8 |
no info in the first 100 Google search result |
|
α9 |
|
α10 |
https://www.google.com/search?client=firefox-b-d&q=nicotinic+acetylcholine+receptor+%CE%B110+subunit
no info in the first 100 Google search result |
|
β1 |
https://www.ncbi.nlm.nih.gov/pubmed/28153524
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=471&familyId=76&familyType=IC
expressed in vertebrate skeletal muscle and placenta |
|
β2 |
https://www.ncbi.nlm.nih.gov/pubmed/21836018
increase attentional performance |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=472&familyId=76&familyType=IC
Knockout mice loss of nicotine-induced dopamine and GABA release, impaired development of the visual system, increased passive avoidance latency; loss of nicotine self-administration, reduced nicotine-induced antinociception, impaired learning and increased neurodegeneration in aged animals |
|
β3 |
https://www.ncbi.nlm.nih.gov/pubmed/31145916
chronic exposure induced withdrawal |
https://f1000.com/prime/725756334
https://www.sciencedirect.com/science/article/abs/pii/S0028390815300800
https://en.wikipedia.org/wiki/CHRNB3
https://www.ncbi.nlm.nih.gov/pubmed/26318101
Modulation of gene expression and increase nicotine consumption |
https://www.jneurosci.org/content/23/35/11045
Modulate Dopamine Release |
|
https://www.ncbi.nlm.nih.gov/pubmed/31145916
hyperalgesia, anhedonia-like effect |
|
β4 |
|
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=474&familyId=76&familyType=IC
Knockout mice display decreased anxiety-related responses; resistance to nicotine-induced seizures; decreased nicotine withdrawal |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869047/
Nicotine intravenous self-administration (IVSA) was lower in constitutive β4 knockout (KO) mice at all doses tested, β4KO mice have higher extracellular dopamine (DA) levels in the nucleus accumbens |
|
γ |
https://www.ncbi.nlm.nih.gov/pubmed/7684117
expressed in adult extraocular muscle and involvement in myasthenia gravis |
|
δ |
https://www.google.com/search?client=firefox-b-d&q=nicotinic+acetylcholine+receptor+%CE%B4+subunit
no info in the first 100 Google search result |
|
ε |
|
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=477&familyId=76&familyType=IC
knockout mice display impaired neuromuscular transmission, progressive muscle weakness and atrophy and associated with the human AChR deficiency syndrome |
|
3.04 |
1 (nicotine) |
α4β2 |
https://en.wikipedia.org/wiki/Nicotine
improvements in attentional performance |
https://en.wikipedia.org/wiki/Varenicline
release of dopamine in the nucleus accumbens |
|
|
|
2.24 |
1,38 (nicotine) |
α2β2 |
|
|
|
16.47 |
3,48 (nicotine) |
α3β2 |
|
|
23.09 |
8,68 (nicotine) |
α4β4 |
|
|
32.35 |
23,5 (nicotine) |
α2β4 |
|
|
21.18 |
37,9 (nicotine) |
α6β4 |
|
|
36.18 |
50,7 (nicotine) |
α6β2 |
|
|
|
60,4 (nicotine) |
α6β3β4α5 |
|
|
230.29 |
92,9 (nicotine) |
α3β4 |
|
https://en.wikipedia.org/wiki/18-Methoxycoronaridine
https://en.wikipedia.org/wiki/18-Methylaminocoronaridine
anti-addiction |
|
Sigma |
σ1 |
https://en.wikipedia.org/wiki/Sigma_receptor
hallucinogenic |
https://en.wikipedia.org/wiki/Sigma_receptor
https://en.wikipedia.org/wiki/PRE-084
nootropic and antidepressant actions in animal studies, as well as antitussive |
https://en.wikipedia.org/wiki/Cutamesine
anti-amnesic |
|
https://en.wikipedia.org/wiki/Sigma_receptor
antipsychotic |
https://en.wikipedia.org/wiki/LR132
https://en.wikipedia.org/wiki/BD1063
decreases the convulsivity |
|
σ2 |
https://en.wikipedia.org/wiki/Sigma-2_receptor
no role in depression |
https://en.wikipedia.org/wiki/Sigma-2_receptor
regulate cholesterol transporter NPC1, involved in cholesterol homeostasis |
|
|
|
glutamate |
transporter |
|
EAAT1 |
|
|
|
|
EAAT2 |
https://en.wikipedia.org/wiki/Excitatory_amino_acid_transporter_2
induce/enhance the expression of EAAT2=reduce the development and expression of tolerance to opiates and other drugs of abuse |
|
https://en.wikipedia.org/wiki/Excitatory_amino_acid_transporter_2
https://en.wikipedia.org/wiki/Acetylcysteine
reduced expression of EAAT2= increase addictive/drug-seeking behavior and increase in vulnerability to relapse after re-exposure to the addictive drug or its associated drug cues |
|
EAAT3 |
https://en.wikipedia.org/wiki/Excitatory_amino_acid_transporter_3
mice lacking EAAT3 exhibit reduced levels of glutathione in neurons, increased oxidative stress, and age-dependent loss of neurons, especially neurons of the substantia nigra. A meta-analysis identified a small but significant association between a polymorphism of the gene SLC1A1 and Obsessive-Compulsive Disorder |
|
EAAT4 |
https://en.wikipedia.org/wiki/Excitatory_amino_acid_transporter_4
see Cerebellumfunction here
https://en.wikipedia.org/wiki/Cerebellum
expressed predominantly in the cerebellum |
|
EAAT5 |
https://en.wikipedia.org/wiki/Excitatory_amino_acid_transporter_5
predominantly in the retina |
|
VGLUT1 |
|
|
VGLUT2 |
|
VGLUT3 |
https://en.wikipedia.org/wiki/Vesicular_glutamate_transporter_3
https://en.wikipedia.org/wiki/Glutamate_transporter#VGLUTs
transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft Mutations in this gene are the cause of autosomal-dominant nonsyndromic deafness modulatory in auditory system it modulates a wide range of neuronal and physiological processes like anxiety, mood regulation, impulsivity, aggressive behavior, pain perception, sleep–wake cycle, appetite, body temperature and sexual behavior. Certainly, no significant change was found in aggression and depression-like behaviors, but in contrast, the loss of VGluT3 resulted in a specific anxiety-related phenotype.
|
|
NR2B=GluN2B
etc..
A 1990 study found an NMDA receptor antagonist, taken concurrently with a benzodiazepine completely eliminated tolerance, dependence, and ultimately withdrawal when use was stopped, on mice or rat. But when NMDA receptor antagonist was used only during withdrawal periods, it had no effect. Whereas an AMPA antagonist nearly eliminated withdrawal during the withdrawal period, but had no effect when taken concurrently, I.e the opposite of the findings of NMDA antagonist.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC47038/
Benzo withdrawal is regarded as very uncomfortable and dangerous, yet no one I’ve interacted with has heard of this or uses it in practice.
https://www.reddit.com/r/DrugNerds/comments/9s1vw5/comment/e8mdzyo/?utm_source=reddit&utm_medium=web2x&context=3
NMDA |
|
NR1 (glycine) |
https://en.wikipedia.org/wiki/GRIN1
plasticity of synapses which is believed to underlie memory and learning |
|
|
|
https://www.reddit.com/r/researchchemicals/comments/eqcqjb/ha966_an_atypical_sedative_anybody_have_any/
https://en.wikipedia.org/wiki/HA-966
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824088/
anxiolytic (emotional blunting not disinhibition), sedative, dissociative feeling (altered state), Reduces pain sensitivity, neuroprotective, distorts visual acuity |
https://en.wikipedia.org/wiki/Apimostinel
https://en.wikipedia.org/wiki/Rapastinel
https://en.wikipedia.org/wiki/Apimostinel
antidepressant |
|
NR2A |
http://www.jneurosci.org/content/early/2018/03/28/JNEUROSCI.0394-18.2018
increase long term pentination |
https://knowingneurons.com/2013/01/28/brain-changes-for-sculpted-efficient-memory/
short-term memory |
|
|
|
NR2B (glutamate) |
https://knowingneurons.com/2013/01/28/brain-changes-for-sculpted-efficient-memory/
long-term memories |
|
https://en.wikipedia.org/wiki/Traxoprodil
https://en.wikipedia.org/wiki/Rislenemdaz
neuroprotective, analgesic, and anti-Parkinsonian and ketamine-like rapidly-acting antidepressant and dissociative |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824088/
reduce anxiety |
|
NR2C |
https://en.wikipedia.org/wiki/GRIN2C
no info |
|
NR2D |
https://en.wikipedia.org/wiki/GRIN2D
long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning |
|
NMDA |
|
|
https://en.wikipedia.org/wiki/NMDA_receptor_antagonist
antidepressant |
>>https://www.quora.com/Can-NMDA-receptor-antagonists-like-ketamine-and-the-arylcyclohexylamines-produce-memory-problems-possibly-permanent
its problem with kitamin and MXE too see
>>https://www.bluelight.org/xf/threads/receptors-function-database.882003/post-14700487
forget links:
in reddit for some one took 2000mg DXM lead to bladder issues
bladder issues |
|
channel (eg, MK-801) |
|
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278809/
attenuate drug cue associations |
|
NR3A |
|
|
|
NR3B |
|
https://you.com/search?q=gene+linked+to+Depersonalization-derealization+disorder&fromSearchBar=true&tbm=youchat
https://www.malacards.org/card/depersonalization_disorder
An important gene associated with Depersonalization Disorder is GRIN3B (Glutamate Ionotropic Receptor NMDA Type Subunit 3B). Studies have suggested that this gene may be linked to the development of depersonalization symptoms [1][2]. Additionally, there have also been studies that suggest an association between stress-linked genes and derealization and depersonalization symptoms.
|
|
NRL1A |
|
|
|
NRL1B |
|
|
AMPA |
|
AMPA |
https://en.wikipedia.org/wiki/Tulrampator
https://en.wikipedia.org/wiki/Sunifiram
motor coordination disruptions, convulsions, and neurotoxicity, enhance cognition and memory, to produce antidepressant-, antianhedonic-, and anxiolytic-like effects, and to have neurotrophic and neuroplasticity-promoting activities. increase levels of BDNF in the hippocampus and to stimulate hippocampal neurogenesis |
https://en.wikipedia.org/wiki/AMPA_receptor_positive_allosteric_modulator
high-impact AMPAR PAMs decrease both deactivation and desensitization together to enhance and prolong synaptic currents |
https://en.wikipedia.org/wiki/Tulrampator
rapidly-acting antidepressant effects of the NMDA receptor antagonist ketamine appear to be mediated through indirect/downstream activation of AMPARs |
https://en.wikipedia.org/wiki/Tulrampator
antidepressant-like effects in animals are blocked by the AMPAR antagonist NBQX |
|
https://en.wikipedia.org/wiki/Becampanel
anticonvulsant |
https://en.wikipedia.org/wiki/Dasolampanel
https://en.wikipedia.org/wiki/Becampanel
https://en.wikipedia.org/wiki/Selurampanel
neuropathic pain |
https://en.wikipedia.org/wiki/Fanapanel
sedation |
|
GRIA1 |
https://en.wikipedia.org/wiki/GRIA1
centrally involved in synaptic plasticity. Expression of the GluR1 gene is significantly reduced in the human frontal cortex with increasing age |
|
GRIA2 |
https://www.ncbi.nlm.nih.gov/pubmed/21248105
regulation of AMPA receptor properties and synaptic plasticity/regulates metabotropic glutamate receptor-dependent long-term depression |
|
GRIA3 |
https://en.wikipedia.org/wiki/GRIA3
https://en.wikipedia.org/wiki/GRIA4
RNA editing allow faster recovery from desensitization therefore allows continue response to stimulant |
|
GRIA4 |
|
Kainate |
|
KA1/GluR5 |
https://en.wikipedia.org/wiki/GRIK4
regulation of antidepressant treatment-response like citalopram |
|
|
|
https://www.ncbi.nlm.nih.gov/pubmed/12724156
protect against seizures |
https://en.wikipedia.org/wiki/Tezampanel
neuroprotective + anticonvulsant + antihyperalgesic + analgesic + anxiolytic |
https://en.wikipedia.org/wiki/Tezampanel
suppresses both the withdrawal symptoms from opioids and the development of tolerance |
|
KA2/GluR6 |
|
https://en.wikipedia.org/wiki/GRIK2
associated with nonsyndromic autosomal recessive mental retardation |
https://www.ncbi.nlm.nih.gov/pubmed/18332879
GluR6 KO mice exhibited less anxious or more risk-taking type behavior and less despair-type manifestations, and they also had more aggressive displays |
|
KA3/GluR7 |
https://en.wikipedia.org/wiki/GRIK3
RNA editing |
|
KA4 |
|
|
|
|
KA5 |
|
|
Metabotropic glutamate receptor |
|
mGluR5 |
https://en.wikipedia.org/wiki/ADX-47273
nootropic and antipsychotic effects |
|
https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_5
https://en.wikipedia.org/wiki/3-((2-Methyl-4-thiazolyl)ethynyl)pyridine
https://en.wikipedia.org/wiki/Fenobam
reduce drug self-administration regardless of dose |
https://en.wikipedia.org/wiki/Lithium_(medication)
learned helplessness |
|
mGluR3 |
https://en.wikipedia.org/wiki/LY-379,268
sedative, neuroprotective, anti-addictive and anticonvulsant |
|
https://en.wikipedia.org/wiki/Eglumegad
anxiolytic effects without producing sedation + slightly reduce cognitive performance + inhibiting the development of tolerance to morphine + relieving the symptoms of withdrawal from chronic use of both nicotine and morphine + reducing the effects of 5HT2A agonist hallucinogens + noticable reduce of yohimbine-induced stress response |
|
https://en.wikipedia.org/wiki/RO4491533
antidepressant |
https://en.wikipedia.org/wiki/LY-341,495
antidepressant increase behavioral effects of hallucinogenic drugs increasing analgesic effects of μ-opioid agonists modulating dopamine receptor function |
https://en.wikipedia.org/wiki/MGS-0039
antagonizing give anxiolytic effect too but its deferent then the anxiolytic effect produced by agonists |
https://en.wikipedia.org/wiki/MGS-0039
antidepressant and anxiolytic + boost release of dopamine and serotonin in specific brain areas |
|
mGluR2 |
https://en.wikipedia.org/wiki/LY-487,379
https://en.wikipedia.org/wiki/ADX-71149
antipsychotic and anxiolytic |
https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_2
auto receptor |
https://en.wikipedia.org/wiki/Biphenylindanone_A
decreases cocaine self-administration in rats, with no effect on food self-administration |
|
|
mGluR1 |
|
|
https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_1
block adrenergic receptor activation in neurons |
https://www.ncbi.nlm.nih.gov/pubmed/18164695
neuroprotective agent for the treatment of stroke. |
https://www.ncbi.nlm.nih.gov/pubmed/17597604
analgesic |
https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_1
Mice lacking mGluR1 had impaired motor functions, characterized by impaired balance. In the Morris watermaze test, an assay for learning abilities, those mice needed significantly more time to successfully complete the task |
|
mGluR1a |
|
https://www.jneurosci.org/content/35/38/13110
significantly inhibited sexual motivation |
|
mGluR4 |
https://en.wikipedia.org/wiki/Foliglurax
https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_4
https://en.wikipedia.org/wiki/PHCCC
treatment of Parkinson's disease |
|
|
|
mGluR7 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923231/
inhibit cocaine and alcohol self-administration |
|
|
mGluR8 |
https://en.wikipedia.org/wiki/DCPG
anticonvulsant + treatment for hyperalgesia |
|
|
mGluR6 |
https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_6
response to light |
|
Orphan |
|
GluD1 |
|
|
|
|
GRID2 |
|
|
GABA |
|
α |
https://en.wikipedia.org/wiki/GABA_receptor_agonist
sedative + relaxing |
|
https://www.ncbi.nlm.nih.gov/pubmed/20655491
antidepressant |
https://en.wikipedia.org/wiki/GABA_receptor_antagonist
stimulant |
|
α1 |
https://en.wikipedia.org/wiki/Zolpidem
induce sleep |
https://en.wikipedia.org/wiki/L-838,417
sedative or amnestic |
|
|
|
α2 |
|
https://en.wikipedia.org/wiki/%CE%915IA
https://en.wikipedia.org/wiki/L-838,417
anxiolytic |
|
|
α3 |
https://en.wikipedia.org/wiki/GABRA3
anxiolytic effects without sedative, amnesia, or ataxia. |
|
|
α4 |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=407
amnesia |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=407
ataxic, sedative, and analgesic effects |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=407
decreases their free consumption of and preference for alcohol |
|
α5 |
|
|
https://en.wikipedia.org/wiki/GABAA_receptor_negative_allosteric_modulator
do not have convulsant or anxiogenic effects but instead show cognitive- and memory-enhancing or nootropic-like effects |
|
α6 |
|
|
|
β |
https://en.wikipedia.org/wiki/GABA_receptor_agonist
sedative + relaxing |
|
https://www.ncbi.nlm.nih.gov/pubmed/20655491
antidepressant |
https://en.wikipedia.org/wiki/GABA_receptor_antagonist
stimulant |
|
β1 |
https://en.wikipedia.org/wiki/Lesogaberan
agonist anticipated to have fewer of the central nervous system side effects that limit the clinical use of baclofen for the treatment of gastroesophageal reflux disease , |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=240
KO show lack of muscle relaxation |
|
β2 |
https://en.wikipedia.org/wiki/Etomidate
anesthetic |
|
|
|
β3 |
https://en.wikipedia.org/wiki/Etomidate
sedation |
|
|
α-ρ1 |
no info at all |
|
ascending aorta, pancreatic ductal cell , tibialis anterior muscle ,deltoid muscle ,left coronary artery ,testicle ,right coronary artery ,placenta ,gastrocnemius muscle ,lower lobe of lung |
α-ρ2 |
https://en.wikipedia.org/wiki/Etifoxine
SSRIs like effect |
https://ar.wikipedia.org/wiki/%D8%A5%D9%8A%D8%AA%D9%8A%D9%81%D9%88%D9%83%D8%B3%D9%8A%D9%86
increase serotonin |
|
|
|
|
α-ρ3 |
|
|
γ1 |
|
|
|
γ2 |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=414&familyId=72&familyType=IC
elevated anxiety + altered emotional behavior reminiscent of melancholic depression + depression related anhedonia in the sucrose consumption test |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=414&familyId=72&familyType=IC
elevated serum corticosterone levels |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=414&familyId=72&familyType=IC
epilepsy |
|
γ3 |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415&familyId=72&familyType=IC
Autism and autism spectrum disorders |
|
δ |
|
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=416&familyId=72&familyType=IC
Knockout females, but not males, show improved fear conditioning |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=416&familyId=72&familyType=IC
Mice lacking the δ subunit show reduced sensitivity to neuroactive steroids |
|
ε |
|
|
|
θ |
|
|
π |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=419&familyId=72&familyType=IC
overexpressed in pancreatic adenocarcinomas |
|
|
opioid |
|
DOR δ1 |
https://en.wikipedia.org/wiki/Opioid_receptor
euphoria |
https://en.wikipedia.org/wiki/Opioid_receptor
physical dependence |
https://en.wikipedia.org/wiki/SNC-80
https://en.wikipedia.org/wiki/DPI-287
https://en.wikipedia.org/wiki/Opioid_receptor
analgesic, antidepressant and anxiolytic effects in animal studies, but its usefulness is limited by producing convulsions at high doses |
|
|
DOR δ2 |
|
|
KOR κ1 |
https://en.wikipedia.org/wiki/Opioid_receptor
https://www.bluelight.org/xf/threads/receptors-function-database.882003/post-14700487
analgesic, anxiogenic |
https://en.wikipedia.org/wiki/%CE%9A-opioid_receptor
suppress itching |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=318
stimulation of prolactin release |
|
|
antidepressent |
|
KOR κ2 |
https://www.jneurosci.org/content/jneuro/14/9/5580.full.pdf
Inhibit NMDA Receptor-mediated Synaptic Currents (dissociative hallucinations) |
|
|
KOR κ3 |
|
|
|
MOR μ1 |
https://en.wikipedia.org/wiki/Opioid_receptor
respiratory depression |
https://en.wikipedia.org/wiki/Opioid_receptor
physical dependence |
https://en.wikipedia.org/wiki/Opioid_receptor
analgesia |
https://www.hcplive.com/view/testosterone-deficiency-a-side-effect-of-opioids
https://link.springer.com/article/10.1007/s40618-018-0964-3
https://en.wikipedia.org/wiki/Opioid-induced_endocrinopathy
Opioids down-regulate the HPA-axis to produce near-castrate testosterone levels, while also suppressing adrenocorticotropic hormone secretion from the anterior pituitary (this lead to decrease libido etc,, effect of low T) |
|
https://www.bluelight.org/xf/threads/managed-to-put-myself-into-opiate-wds-advice-needed.898547/
Restless legs syndrome |
https://www.bluelight.org/xf/threads/kratom-withdrawal-severity.903562/
increased sensitivity to physical touch and pain |
|
opioid agonists increase and opioid antagonist decrease food intake
https://www.nature.com/articles/s41467-018-03848-y
the opiates Mu2 give you sense of contentment
>>https://www.reddit.com/r/Psychonaut/comments/f6luui/willing_to_start_codeine_as_antidepressant_make/fi62ppp/?context=3
MOR μ2 |
https://en.wikipedia.org/wiki/Opioid_receptor
euphoria |
|
|
MOR μ3 |
|
|
|
NOR |
https://en.wikipedia.org/wiki/Nociceptin_receptor
depression |
https://en.wikipedia.org/wiki/Opioid_receptor
development of tolerance to μ-opioid agonists |
|
|
|
NOR ORL1 |
|
|
|
ZOR |
https://en.wikipedia.org/wiki/Opioid_receptor
tissue growth |
|
|
NOP |
|
|
https://en.wikipedia.org/wiki/Nociceptin_receptor
treatments for depression and Parkinson's disease |
|
ACKR3 |
In 2011, the Bohn lab noted antinociception against both chemically induced and inflammation-derived pain, and experiments indicated lack of opioid receptor inhibition, but were unable to define a particular target. A 2019 study by a cross-site Australian and U.S. group discovered through cultured neuronal networks that conolidine may inhibit the Ca v2.2 channel, a mechanism seen in molecules like conotoxin. The group was unable to rule out partial polypharmacology against other targets.[8] It has been discovered to bind to novel opioid receptor ACKR3/CXCR7. By binding to that receptor, the endogenous opioid peptides (such as endorphins and enkephalins) cannot be trapped thus increasing availability of those peptides to their target sites.[9] |
|
CXCR7 |
|
trace amine receptors |
|
0.71 (dopamine) |
TAAR1 |
https://en.wikipedia.org/wiki/Dextroamphetamine
decrease Serotonin, Noradrenaline, Dopamine, reuptake |
|
|
|
|
TAAR2 |
not about depression |
|
TAAR5 |
|
TAAR6 |
|
TAAR8 |
|
TAAR9 |
|
COMT |
|
|
https://en.wikipedia.org/wiki/Catechol-O-methyltransferase
convert catecholamine's to rubbish |
|
https://en.wikipedia.org/wiki/Catechol-O-methyltransferase
stop convert catecholamine's to rubbish |
https://en.wikipedia.org/wiki/Entacapone
+levodopa |
|
fos |
|
ΔFosB |
happiness seeking behaviors (craving) |
|
anti-craving effect |
|
c-Fos |
https://en.wikipedia.org/wiki/C-Fos
don't increase the chronic induction of ΔFosB |
|
https://en.wikipedia.org/wiki/C-Fos
increase the chronic induction of ΔFosB |
|
adenosine |
|
A1 |
https://en.wikipedia.org/wiki/Tianeptine
anticonvulsant and analgesic |
|
https://selfhacked.com/blog/caffeine-benefits/
https://en.wikipedia.org/wiki/Caffeine
feel more energized and awake + heart-pounding effects |
|
SAM-e appears to suppress the expression of adenosine receptor A2A
>>https://www.longecity.org/forum/topic/106343-sam-e-appears-to-suppress-the-expression-of-adenosine-receptor-a2a/
A2A |
|
|
https://en.wikipedia.org/wiki/Caffeine
wakefulness-promoting effects, Antagonism of A2A receptors in the ventrolateral preoptic area reduces inhibitory GABA neurotransmission to the tuberomammillary nucleus, a histaminergic projection nucleus that activation-dependently promotes arousal |
|
A2B |
provide protection from ischemia (lack of oxygen due to blocked blood supply) |
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1577-2
promotes progression of human oral cancer |
|
anti-inflammatory |
https://pubmed.ncbi.nlm.nih.gov/10101031/
inhibits release of interleukins that is involved in the development of spatial memories |
|
A3 |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=21
https://en.wikipedia.org/wiki/CP-532,903
https://en.wikipedia.org/wiki/Adenosine_A3_receptor
anti-inflammatory |
|
|
|
cAMP |
|
|
stimulant |
|
|
oxidants |
|
|
|
|
decrease cell death due oxidative stress |
smooth skin (anti-aging effect) |
|
PDE |
|
1 |
|
|
https://en.wikipedia.org/wiki/PDE1
increase cAMP used in: Parkinson's disease, Alzheimer's disease, Epilepsy |
|
1B |
|
https://www.sciencedirect.com/science/article/abs/pii/S0167732221022091
D1 receptor potentiation |
|
2 |
|
https://en.wikipedia.org/wiki/Phosphodiesterase_2
increase cAMP used in: improving memory |
|
3 |
|
https://en.wikipedia.org/wiki/PDE3_inhibitor
increase cAMP used in: acute heart failure and cardiogenic shock |
|
4 |
|
https://www.longecity.org/forum/topic/104031-pde4is-as-antidepressant-who-has-tried-it/#entry868963
https://en.wikipedia.org/wiki/Phosphodiesterase-4_inhibitor
increase cAMP used in: precognitive (including long-term memory-improving), wakefulness-promoting, neuroprotective, and anti-inflammatory effects |
|
4B |
|
https://chat.nootropicsrebirth.com/channel/c-rock-inhibition
could be considered anti nootropic depending on dose |
|
4D |
|
https://chat.nootropicsrebirth.com/channel/c-rock-inhibition
nausea |
|
5 |
|
https://en.wikipedia.org/wiki/PDE5_inhibitor
increase cAMP used in: erectile dysfunction |
|
6 |
|
https://en.wikipedia.org/wiki/Cyclic_guanosine_monophosphate
https://en.wikipedia.org/wiki/PDE6
loss of visual sensitivity but is unlikely to impair common visual tasks, except under conditions of reduced visibility when objects are already near visual threshold |
|
7 |
|
https://en.wikipedia.org/wiki/Phosphodiesterase_inhibitor
increase cAMP used in: anti-inflammatory and neuroprotective |
https://www.longecity.org/forum/topic/104975-s14-relief-from-anhedonia-and-induction-of-dopaminergic-neurogenesis/#entry872786
induction of dopaminergic neurogenesis |
|
10 |
https://en.wikipedia.org/wiki/Papaverine
motor and cognitive deficits and increased anxiety |
|
https://en.wikipedia.org/wiki/Papaverine
https://en.wikipedia.org/wiki/Tofisopam
https://en.wikipedia.org/wiki/Phosphodiesterase_inhibitor
increase cAMP used in: erectile dysfunction, treatment for schizophrenia |
|
10A |
|
|
https://www.sciencedirect.com/science/article/abs/pii/S0167732221022091
D2 receptor suppression |
|
9 |
|
https://en.wikipedia.org/wiki/BAY_73-6691
increase cAMP used in: improve learning and memory |
|
11 |
https://www.sciencedirect.com/science/article/pii/S1074552111004625
poorly understood, in part due to the lack of selective inhibitors |
|
Oxytocin |
|
Oxytocin |
https://en.wikipedia.org/wiki/Oxytocin
love (mostly because androgen Neurotransmitter "Oxytocin" have wake biding affinity to Vasopressin 1A) |
|
|
|
Vasopressin |
|
1A |
https://en.wikipedia.org/wiki/Vasopressin_receptor_1A
social recognition (mostly this is empathy of SSRIs + testosterone directly suppresses oxytocin in mice) |
https://en.wikipedia.org/wiki/Oxytocin
Romantic attachment (physical and physiological) |
https://en.wikipedia.org/wiki/Oxytocin
emotional talk + increase ability to trust others + increase generosity |
https://en.wikipedia.org/wiki/Oxytocin
Oxytocin evokes feelings of contentment, reductions in anxiety, and feelings of calmness and security when you are with your friend |
|
https://en.wikipedia.org/wiki/Vasopressin_receptor_1A
reduced anxiety-like behavior |
https://en.wikipedia.org/wiki/Vasopressin_receptor_1A
greatly impaired social recognition abilities |
https://en.wikipedia.org/wiki/Vasopressin_receptor_1A
social isolation |
https://en.wikipedia.org/wiki/Vasopressin_receptor_1A
deficits in circadian rhythms and olfaction |
|
1B |
https://en.wikipedia.org/wiki/Arginine_vasopressin_receptor_1B
aggression |
https://en.wikipedia.org/wiki/Vasopressin_receptor_1B
ability to recognize recently investigated mice |
|
https://en.wikipedia.org/wiki/Arginine_vasopressin_receptor_1B
reduced social motivation or awareness |
|
2 |
https://en.wikipedia.org/wiki/Vasopressin_receptor_2
antidiuretic |
|
|
|
Orexin |
|
OX1 |
https://en.wikipedia.org/wiki/Orexin
happiness |
https://en.wikipedia.org/wiki/Orexin
happiness seeking behaviors |
https://en.wikipedia.org/wiki/Orexin
wakefulness + regulates energy expenditure + increase appetite + body temperature and locomotion |
|
https://en.wikipedia.org/wiki/Orexin
treatment of cocaine, opioid, and alcohol nicotine addiction |
https://en.wikipedia.org/wiki/Suvorexant
Other concerns include thoughts of suicide |
|
OX2 |
|
|
https://en.wikipedia.org/wiki/Orexin
studies in rats using the dual orexin receptor antagonist TCS 1102 have not found similar effects in nicotine addiction |
https://en.wikipedia.org/wiki/JNJ-10397049
sleep-promoting effects and to attenuate the reinforcing effects of ethanol and mostly other drugs |
|
P-glycoprotein |
|
|
https://en.wikipedia.org/wiki/Quinidine
https://en.wikipedia.org/wiki/Paliperidone
prevent drugs from across BBB (involved in tolerance) |
|
https://en.wikipedia.org/wiki/Quinidine
cause some peripherally acting drugs to have central nervous system action too |
|
estrogen |
main |
|
ERα |
https://en.wikipedia.org/wiki/GTx-758
https://en.wikipedia.org/wiki/Estrogen_receptor_alpha
induced increase in SHBG which lower free testosterone + upregulation of gonadal testosterone production due to reduced negative feedback by androgens on the hypothalamic–pituitary–gonadal axis |
https://en.wikipedia.org/wiki/Estrogen_receptor_alpha
undersized testes, stimulate cell proliferation in breast tissue |
https://en.wikipedia.org/wiki/Estrogen_receptor_alpha
maintenance of bone integrity |
https://en.wikipedia.org/wiki/GPER
antidepressant-like effects |
|
|
|
ERβ interacts with metabotropic glutamate receptor 1a (mGluR1a)
>>https://www.jneurosci.org/content/35/38/13110
Erβ |
https://en.wikipedia.org/wiki/Estrogen_receptor_beta
anti-proliferative in reproductive tissue |
https://en.wikipedia.org/wiki/GPER
anxiolytic |
https://en.wikipedia.org/wiki/3%CE%B2-Androstanediol
https://en.wikipedia.org/wiki/WAY-200070
antidepressant, anxiolytic, cognitive-enhancing, and stress-relieving |
https://en.wikipedia.org/wiki/3%CE%B2-Androstanediol
up-regulates oxytocin receptors |
https://www.jneurosci.org/content/35/38/13110
increase sexual motivation |
|
https://en.wikipedia.org/wiki/Estrogen_receptor_beta
https://en.wikipedia.org/wiki/Erteberel
cognitive impairment , and development of AD pathology |
https://en.wikipedia.org/wiki/Estrogen_receptor_beta
Abnormalities in gene expression associated with ER-β have also been linked to autism spectrum disorder |
|
GPER |
https://en.wikipedia.org/wiki/GPER
GPER and ERβ play a modulator role in breast development, ERα is the main receptor responsible for estrogen-mediated breast tissue growth |
https://en.wikipedia.org/wiki/GPER
anxiogenic |
https://en.wikipedia.org/wiki/GPER
Lordosis to front |
|
|
|
Estrogen-related receptor |
|
ERRα |
|
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=622&familyId=97&familyType=NHR
ERRalpha KO mice:-reduced body weight, resistant to high-fat diet induced obesity |
|
ERRβ |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=623&familyId=97&familyType=NHR
ERRβ Null Mice: show severely impaired placental formation. |
|
ERRγ |
https://omictools.com/993460020c8f1ee79455400ac90c13e2-protocol
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=624&familyId=97&familyType=NHR
protect pre-menopausal women from age-related hearing loss |
|
|
|
Membrane estrogen receptor |
|
Gq-mER |
https://en.wikipedia.org/wiki/Membrane_estrogen_receptor
no info |
|
Erx |
|
ER-X |
|
Androgen receptor |
|
AR |
https://en.wikipedia.org/wiki/Androgen_receptor
have important role in prostate cancer |
|
|
|
GPRC6A |
https://en.wikipedia.org/wiki/GPRC6A
mediate rapid, non-genomic prostate cancer cell responses to testosterone |
https://en.wikipedia.org/wiki/Membrane_androgen_receptor
increase skeletal muscle strength, indicating potential anabolic effects, implicated in the antigonadotropic effects of androgens |
|
14nM(Kd) |
|
Testosterone has high affinity for ZIP9 with a Kd of 14 nM and acts as an agonist of the receptor.
>>https://en.wikipedia.org/wiki/Zinc_transporter_ZIP9
ZIP9 |
https://en.wikipedia.org/wiki/Membrane_androgen_receptor
increase skeletal muscle strength, indicating potential anabolic effects, implicated in the antigonadotropic effects of androgens |
|
progesterone receptor |
|
PR-A |
https://en.wikipedia.org/wiki/Progesterone_receptor
serve to antagonize the effects of PR-B |
|
https://en.wikipedia.org/wiki/Progesterone_receptor
delayed but otherwise normal mammary ductal development at puberty |
https://en.wikipedia.org/wiki/Progesterone_receptor
impaired lobuloalveolar development of the mammary glands |
|
PR-B |
https://en.wikipedia.org/wiki/Progesterone_receptor
positive regulator of the effects of progesterone |
|
|
PR-C |
|
|
|
mPRγ |
Wikipedia
no info |
|
mPRδ |
|
mPRα |
|
mPRβ |
|
mPRϵ |
|
AdipoR1 |
|
AdipoR2 |
|
Glucocorticoid receptor |
|
NR3C1 |
https://en.wikipedia.org/wiki/Glucocorticoid_receptor
https://en.wikipedia.org/wiki/Mineralocorticoid
LINKED TO PTSD |
|
Mineralocorticoid |
|
|
Cannabinoid |
|
CB1 |
https://en.wikipedia.org/wiki/Yangonin
anxiolytic |
https://www.bluelight.org/xf/threads/receptors-function-database.882003/post-14700487
"THC acts as a CB1 agonist. As a CB1 antagonist, THCV has been shown to reduce appetite in murine"
>>https://en.wikipedia.org/wiki/Tetrahydrocannabivarin
https://en.wikipedia.org/wiki/Cannabinoid
increase appetite, novelty, appreciation for food, music, art, analgesic, decrease short-term memory |
|
|
|
CB2 |
https://en.wikipedia.org/wiki/JWH-133
anti-inflammation |
https://en.wikipedia.org/wiki/JWH-133
preventing cognitive impairment and loss of neuronal markers |
https://en.wikipedia.org/wiki/JWH-133
anti-cancer properties |
|
|
NAGly (GPR18) |
https://en.wikipedia.org/wiki/NAGly_receptor
anti-inflammatory |
https://en.wikipedia.org/wiki/Abnormal_cannabidiol
without producing any psychoactive effects |
|
|
GPR55 |
https://en.wikipedia.org/wiki/GPR55
altered blood pressure regulation |
|
GPR119 |
https://en.wikipedia.org/wiki/GPR119
body weight loss by reduction in food intake |
|
|
|
inhibits the production of the second messenger cAMP from ATP.
>>https://en.wikipedia.org/wiki/Neuropeptide_Y_receptor
Neuropeptide Y receptor |
|
Y1 |
|
|
https://en.wikipedia.org/wiki/BIBP-3226
regulation of appetite, anxiety, BIBP-3226 has anxiogenic and anorectic effects |
|
presynaptic autoreceptor limiting further neuropeptide Y release
>>https://en.wikipedia.org/wiki/BIIE-0246
Y2 |
|
https://en.wikipedia.org/wiki/BIIE-0246
reducing alcohol consumption in addicted rats[6][7] and anxiolytic effects |
|
Y4 |
|
|
|
Y5 |
|
https://en.wikipedia.org/wiki/Lu_AA-33810
anorectic, antidepressant and anxiolytic effects |
|
peroxisome proliferator-activated receptor |
|
PPAR-α |
https://examine.com/supplements/oleoylethanolamide/research/#Yl1DjJP-neurology_Yl1DjJP-miscellaneous-mechanisms
feeling of satiety after meals |
|
|
|
PPAR-delta |
https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor_delta
changes the body's fuel preference from glucose to lipids.[19] |
https://en.wikipedia.org/wiki/GW501516
sport doping agent |
|
|
PPAR-γ |
uprgulate SERT + increase production of serotonin (the result is antidepressant effect) |
https://www.sciencedirect.com/science/article/pii/S0306452221005479
upregulates GABARα2 |
https://www.sciencedirect.com/science/article/pii/S0306452221005479
impair motivation and associative learning |
https://www.sciencedirect.com/science/article/pii/S0306452221005479
some phychological effect of diet-induced obesity |
|
|
Melanocortin |
|
MC1R |
https://en.wikipedia.org/wiki/%CE%91-MSH
https://en.wikipedia.org/wiki/Melanocortin_1_receptor
hyperpigmentation primarily of the hair and skin |
|
https://en.wikipedia.org/wiki/Melanocortin_1_receptor
decrease sensitivity to pain |
|
MC2R |
https://en.wikipedia.org/wiki/ACTH_receptor
upregulates levels of cAMP by activating adenylyl cyclase |
|
|
|
MC3R |
|
|
https://en.wikipedia.org/wiki/Melanocortin_3_receptor
increased fat mass despite decreased food intake |
|
MC4R |
"treatment of erectile dysfunction"
https://en.wikipedia.org/wiki/PF-00446687
"treatment of female sexual dysfunction and erectile dysfunction"
https://en.wikipedia.org/wiki/PL-6983
"powerful potential treatments for both female and male sexual dysfunction, including hypoactive sexual desire disorder and erectile dysfunction"
https://en.wikipedia.org/wiki/Melanocortin_4_receptor
"THIQ stimulated sexual activity in rats"
https://en.wikipedia.org/wiki/THIQ
powerful treatments for female and male sexual dysfunction |
https://en.wikipedia.org/wiki/Melanocortin_4_receptor
via activation of the central oxytocin system, have been found to promote pair bond |
|
"MC4 receptor antagonists produce pronounced antidepressant- and anxiolytic-like effects in animal models of depression and anxiety"
https://en.wikipedia.org/wiki/Melanocortin_4_receptor
produce pronounced antidepressant- and anxiolytic-like effects |
"Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity"
https://pubs.acs.org/doi/10.1021/jm058241a
"MC4R mutations were reported to be associated with inherited human obesity"
https://en.wikipedia.org/wiki/Melanocortin_4_receptor
Obesity |
|
MC5R |
|
|
https://en.wikipedia.org/wiki/Melanocortin_5_receptor
male mice decreases aggressive behavior, promotes defensive behavior and encourages other male mice to attack MC5R-deficient males through pheremonal signals |
https://en.wikipedia.org/wiki/Melanocortin_5_receptor
decreased production of sebum |
|
Thyroid hormones |
|
T3 |
https://en.wikipedia.org/wiki/Liothyronine
weight loss, tremor, headache, upset stomach, vomiting, diarrhea, stomach cramps nervousness, irritability, insomnia, excessive sweating, increased appetite, fever, changes in menstrual cycle, sensitivity to heat |
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|
|
ZINC RECEPTOR |
|
GPR39 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790399/
SSRIs upregulate this (involved in the antidepressant response) |
|
|
Histone deacetylase |
|
HDAC2 |
|
|
https://en.wikipedia.org/wiki/Histone_deacetylase_2
treatment for Parkinson's Disease |
https://en.wikipedia.org/wiki/Histone_deacetylase_2
prevented cognitive and behavioral impairments in mice with Alzheimer's Disease |
|
HDAC1 |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2658
==>Tacedinaline
https://www.frontiersin.org/articles/10.3389/fnins.2021.674745/full
showed increased acetylation of histone marks H3K27ac and H3K18ac at the dopamine 2 receptor (D2R) gene (Drd2) promoter and increased expression of the Drd2 mRNA and D2R protein in the striatum |
|
HDAC3 |
|
|
HDAC4 |
https://en.wikipedia.org/wiki/HDAC4
regulates bone and muscle development |
|
HDAC5 |
https://en.wikipedia.org/wiki/Histone_deacetylase_5
involved in memory consolidation |
|
HDAC6 |
https://en.wikipedia.org/wiki/HDAC6
Mutations in this gene have been associated to Alzheimer's disease |
|
HDAC8 |
|
|
|
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HDAC9 |
|
|
HDAC10 |
https://en.wikipedia.org/wiki/HDAC10
HDAC10 has been shown to interact with Histone deacetylase 2, and Nuclear receptor co-repressor 2 |
|
HDAC11 |
https://en.wikipedia.org/wiki/HDAC11
upregulation of HDAC11 expression has also been seen in various cancer cells |
|
Sirtuin |
https://en.wikipedia.org/wiki/Sirtuin
implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation ( nicotinamide inhibit this) |
|
acetylation marks |
H3K27ac |
Author:
ibtisam: H3K27ac is well recognized as a marker for active enhancers and a great indicator of enhancer activity
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-01957-w
(promoter) |
|
|
|
H3K18ac |
Author:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562857/#:~:text=Acetylation%20of%20histone%203%20at,%2C%20prostate%2C%20and%20thyroid%20cancer.
plays an important role in driving progression of many types of cancer, including breast, colon, lung, hepatocellular, pancreatic, prostate, and thyroid cancer |
|
|
COX |
|
COX-1 |
|
|
|
|
COX-2 |
|
https://en.wikipedia.org/wiki/COX-2_inhibitor
suppressing inflammatory neurodegenerative pathways in mental illness |
|
Neurotensin |
|
NTS1 |
|
|
https://en.wikipedia.org/wiki/SR-142948
blocked the effects of stimulant drugs including MDMA |
|
NTS2 |
|
|
GHB receptor |
|
GPR172A |
https://en.wikipedia.org/wiki/GHB_receptor
https://en.wikipedia.org/wiki/NCS-382
https://en.wikipedia.org/wiki/3-Chloropropanoic_acid
do not produce a sedative effect, instead causing a stimulant effect followed by convulsions at higher doses, thought to be mediated through increased Na+/K+ current and increased release of dopamine and glutamate |
|
|
|
Angiotensin II |
|
AT1 |
https://en.wikipedia.org/wiki/Angiotensin_II_receptor_type_1
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=34&familyId=6&familyType=GPCR
increase vasoconstriction, aldosterone synthesis and secretion, increased vasopressin secretion |
|
https://en.wikipedia.org/wiki/Angiotensin_II_receptor_type_1
reduce fear memory recall |
|
AT2 |
https://en.wikipedia.org/wiki/Angiotensin_II_receptor
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=35&familyId=6&familyType=GPCR
inhibition of cell growth |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=35&familyId=6&familyType=GPCR
Over expression of the AT2 receptor down-regulated the AT1 receptor |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=35&familyId=6&familyType=GPCR
Decrease of dopamine synthesis |
|
|
|
AT3 |
no info in the first 100 Google search result |
|
AT4 |
https://www.ncbi.nlm.nih.gov/pubmed/20224888
https://en.wikipedia.org/wiki/Angiotensin_II_receptor
induce release of oxytocin (anxiolytic effect) |
https://www.ncbi.nlm.nih.gov/pubmed/12591177
https://www.ncbi.nlm.nih.gov/pubmed/15549174
https://www.ncbi.nlm.nih.gov/pubmed/16343778
https://www.ncbi.nlm.nih.gov/pubmed/21719467
enhances learning and memory and cognition |
|
|
|
vitamin D receptor |
|
VDR |
https://medlineplus.gov/vitaminddeficiency.html
increase calcium absorption |
|
https://medlineplus.gov/vitaminddeficiency.html
loss of bone density |
|
https://www.frontiersin.org/articles/10.3389/fimmu.2013.00148/full
https://www.lifeextension.com/magazine/2013/8/the-overlooked-importance-of-vitamin-d-receptors
regulates the expression of more than 900 genes (cell growth and development, immune function, and metabolic control) |
|
Melatonin |
|
MT1 |
|
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=287
MT1 receptor knockout mice exhibit depression-like behaviour and reduced mobility in the forced swim test compared to wild-type mice. |
|
MT2 |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=288
MT2 receptor knockout mice do not exhibit luzindole-mediated antidepressant-like actions, as seen in wild-type mice. |
|
GPR50 |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=107
Physiological function of GPR50 remains unclear, although studies implicate the receptor in energy homeostasis [12]. |
|
calcium |
|
α2δ-1 |
|
|
https://en.wikipedia.org/wiki/Gabapentin
anticonvulsant, analgesic, and anxiolytic effects (opiates and benzo-like effect) |
|
Sodium |
|
Nav1.2 |
|
|
https://en.wikipedia.org/wiki/Nav1.2
mutations in this gene have been linked to several seizure disorders and autism, infantile spasms bitemporal glucose hypometabolism , and bipolar disorder |
|
Nav1.3 |
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=580&familyId=82&familyType=IC
anti-Neuropathic pain |
|
Nav1.4 |
|
https://en.wikipedia.org/wiki/Nav1.4
Mutations in the gene are associated with hypokalemic periodic paralysis, hyperkalemic periodic paralysis, paramyotonia congenita, and potassium-aggravated myotonia |
|
Nav1.5 |
|
https://en.wikipedia.org/wiki/Nav1.5
cardiac diseases is associated with mutations (Long QT syndrome type 3) |
|
Nav1.8 |
|
https://en.wikipedia.org/wiki/Nav1.8
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=585&familyId=82&familyType=IC
treatment of chronic pain |
|
Nav1.9 |
|
https://en.wikipedia.org/wiki/Nav1.9
pain relief |
https://en.wikipedia.org/wiki/Nav1.9
anti-inflammatory |
|
Potassium channels |
|
K2P2.1 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093650/
anxiolytic and antidepressive effect |
|
|
|
Kv7.1 |
|
|
https://en.wikipedia.org/wiki/KvLQT1
Mutations in the gene can lead to a defective protein and several forms of inherited arrhythmias as Long QT syndrome, Short QT syndrome, and Familial Atrial Fibrillation |
|
Kv7.2 |
|
https://en.wikipedia.org/wiki/Retigabine
https://en.wikipedia.org/wiki/KvLQT2
anticonvulsants |
|
G protein-coupled receptor kinase |
|
GRK6 |
|
|
https://www.cell.com/neuron/fulltext/S0896-6273(03)00192-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627303001922%3Fshowall%3Dtrue
https://en.m.wikipedia.org/wiki/G_protein-coupled_receptor_kinase
upregulate D2/D3 receptor |
https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1471-4159.2001.00268.x
upregulate mu-opiates receptors |
|
GRK2 |
https://pubmed.ncbi.nlm.nih.gov/8631993/
The agonist-dependent phosphorylation of the rat D1A receptor was substantially increased |
|
https://en.wikipedia.org/wiki/Paroxetine
https://en.wikipedia.org/wiki/G_protein-coupled_receptor_kinase_2
https://www.jbc.org/article/S0021-9258(20)72281-7/fulltext
upregulate β2 adrenergic receptors |
https://www.uniprot.org/uniprot/P35372
https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1471-4159.2001.00268.x
https://www.jbc.org/article/S0021-9258(20)72281-7/fulltext
"Arrestin beta 2 is crucial for the development of tolerance to morphine and other opioids." https://en.wikipedia.org/wiki/Arrestin_beta_2
upregulate mu-opiates receptors |
|
GRK3 |
|
https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1471-4159.2001.00268.x
https://www.frontiersin.org/articles/10.3389/fphar.2014.00280/full
upregulate mu-opiates receptors |
https://www.frontiersin.org/articles/10.3389/fphar.2014.00280/full
upregulate KOR-opiates receptors |
|
GRK5 |
|
|
|
completely searched in https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=695
Retinoid receptor |
|
RAR-alpha 1 |
|
|
https://en.wikipedia.org/wiki/Retinoic_acid_receptor_alpha
Knock-out mice studies showed that a deletion in one of the copies of the RARA gene did not create any observable defect, while deletion of both copies shoes symptoms similar to that of Vitamin A deficiency. This proved that all 3 subtypes of RARs work redundantly. |
https://www.sciencedirect.com/science/article/abs/pii/S0361923018308190
Ro41-5253 (1 mg/kg) treatment downregulated RARα protein expression in hypothalamic PVN and hypothalamus, and increased the protein levels of BDNF, PSD95, SYP and MAP2 in the hippocampus. We concluded that Ro41-5253 had antidepressant-like effects on CUMS rats by downregulating HPA axis hyperactivity and improving the hippocampal neuronal deficits |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24972/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473493/
as the absence of retinoid receptors results in a reduced expression of the DA D2 receptor/mutations for the acid retinoic receptors demonstrated in mice could reduce expression of D1 and D2 receptors and do impair dopamine signaling |
|
RAR-alpha 2 |
|
|
RAR-alpha 3 |
|
|
RAR-beta |
https://en.wikipedia.org/wiki/Retinoic_acid_receptor_beta
limits growth of many cell types by regulating gene expression |
mentioned by friend (alessandro)
upregulate dopamine 2 receptors |
|
https://en.wikipedia.org/wiki/Retinoic_acid_receptor_beta
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128494/
associated with cancer onset/progression |
|
RAR-gamma |
https://en.wikipedia.org/wiki/Retinoic_acid_receptor_gamma
shown to interact with NCOR1 |
Depression, Mood changes, Suicidal ideation |
https://en.wikipedia.org/wiki/Alitretinoin
https://en.wikipedia.org/wiki/Retinoid_X_receptor
anti-cancer |
|
|
|
RXR |
https://en.wikipedia.org/wiki/Bexarotene
downregulation of thyroid stimulating hormone |
https://pubmed.ncbi.nlm.nih.gov/24434091/
significant increase in cholesterol levels and a decrease in total thyroxine levels |
|
|
Tissue Distribution Click here for help:Liver, lung, muscle, kidney, epidermis, intestine, skin
RXR-alpha |
https://en.wikipedia.org/wiki/Retinoid_X_receptor_alpha
regulating their transcription (unknown what it is) |
|
https://en.wikipedia.org/wiki/Retinoid_X_receptor
RXR heterodimer in the absence of ligand is bound to hormone response elements complexed with corepressor protein. Binding of agonist ligands to RXR results in dissociation of corepressor and recruitment of coactivator protein, which, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein. |
|
|
RXR-beta |
https://en.wikipedia.org/wiki/Retinoid_X_receptor_beta
involved in mediating the effects of retinoic acid (RA). This increasing both DNA binding and transcriptional function on their respective response elements |
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=611&familyId=92&familyType=NHR
Induction of apoptosis (associated to RARa activation) |
|
|
RXR-gamma |
https://en.wikipedia.org/wiki/Retinoid_X_receptor_gamma
the antiproliferative effects of retinoic acid (RA). |
https://www.selleckchem.com/retinoid-receptor.html
confirmed by by friend (alessandro): 40% of the D2 receptors are transcribed by the RARb-RXRy heterodimer
Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne (which make sure that rxr is upregulate ht1a presynpatic receptors and dopamine 2) |
very strong acne treatment |
https://journals.physiology.org/doi/full/10.1152/ajpendo.00313.2001
https://en.wikipedia.org/wiki/Retinoid_X_receptor_gamma
suppression of thyroid function |
|
https://pubmed.ncbi.nlm.nih.gov/20620876/
ablation of Rxrgamma in mice leads to depressive-like behaviors including increased despair and anhedonia, which were accompanied by reduced expression of dopamine D2 receptor in the shell of nucleus accumbens (NAc) and altered serotonin signaling (proberly increase singling of serotonin) |
|
Nuclear receptor |
NCOR1 |
https://en.wikipedia.org/wiki/Nuclear_receptor_co-repressor_2
https://en.wikipedia.org/wiki/Nuclear_receptor_co-repressor_1
assists nuclear receptors in the down regulation of target gene expression (unknown what it is) |
|
https://en.wikipedia.org/wiki/Nuclear_receptor_co-repressor_1
Loss of function of this protein significantly increases the strength and power of mouse muscles |
|
NCOR2 |
|
|
|
Neurokinin |
|
TACR1 |
https://en.wikipedia.org/wiki/Tachykinin_receptor_1
https://en.wikipedia.org/wiki/Vestipitant
https://en.wikipedia.org/wiki/L-733,060
has been associated with the transmission of stress signals and pain |
|
https://en.wikipedia.org/wiki/Aprepitant
99% human receptor occupancy might be required for consistent psycho-pharmacological or other therapeutic effects |
https://en.wikipedia.org/wiki/Aprepitant
https://en.wikipedia.org/wiki/Casopitant
https://en.wikipedia.org/wiki/Maropitant
prevent chemotherapy-induced nausea and vomiting |
https://en.wikipedia.org/wiki/Maropitant
anti-pain |
|
TACR2 |
|
|
https://en.wikipedia.org/wiki/Saredutant
https://en.wikipedia.org/wiki/GR-159897
antidepressant and anxiolytic |
https://en.wikipedia.org/wiki/GR-159897
treatment of asthma |
|
TACR3 |
|
https://en.wikipedia.org/wiki/Fezolinetant
https://en.wikipedia.org/wiki/Pavinetant
dose-dependently suppress luteinizing hormone (LH) secretion, though not that of follicle-stimulating hormone (FSH), and consequently to dose-dependently decrease estradiol and progesterone levels in women and testosterone levels in men |
|
orphan receptors |
|
GPR35 |
https://en.wikipedia.org/wiki/Pamoic_acid
https://en.wikipedia.org/wiki/Lodoxamide
activates ERK and beta-arrestin2, and causes antinociceptive activity (increase pain sensitivity) |
https://en.wikipedia.org/wiki/Lodoxamide
https://en.wikipedia.org/wiki/GPR35
development of stomach cancer |
https://en.wikipedia.org/wiki/Lodoxamide
inflammatory processes |
|
|
|
transient receptor potential channel |
|
TRPA1 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567430/
sensor of noxious cold |
https://en.m.wikipedia.org/wiki/TRPV1
"Desensitization of TRPV1 is thought to underlie the paradoxical analgesic effect of capsaicin." " a recent report, it was found that tonically active TRPV1 channels are present in the viscera and keep an ongoing suppressive effect on body temperature"
|
https://en.m.wikipedia.org/wiki/TRPV1
"TRPV1 was shown to have protective effect in neurologic disorders such as vascular dementia" link to chilli caused me better blood follow in brain |
|
https://en.m.wikipedia.org/wiki/TRPV1
AMG-517, a highly selective TRPV1 antagonist was dropped out of clinical trials due to the causation of hyperthermia |
|
https://en.m.wikipedia.org/wiki/TRPV1
Eight percent capsaicin patches have recently become available for clinical use, with supporting evidence demonstrating that a 30-minute treatment can provide up to 3 months analgesia by causing regression of TRPV1-containing neurons in the skin, Currently, these treatments must be re-administered on a regular (albeit infrequent) schedule in order to maintain their analgesic effects.
|
https://en.m.wikipedia.org/wiki/TRPV1
AM404 also serves as a potent TRPV1 agonist, cannabinoid cannabidiol also shows "either direct or indirect activation" of TRPV1 receptors |
https://en.m.wikipedia.org/wiki/TRPV1
proposed as a target for treatment not only of pain but also for other conditions such as anxiety, TRPV1 appears to mediate long-term synaptic depression (LTD) in the hippocampus |
|
|
|
TRPV3 |
|
|
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=509
impaired thermosensation, display a wavy hair coat and curly whiskers and have dry and scaly skin. |
|
TRPC6 |
>>https://en.wikipedia.org/wiki/Adhyperforin
inhibiting the reuptake of various neurotransmitters including serotonin, norepinephrine, dopamine, GABA, and glutamate |
|
|
|
TRPM8 |
https://en.wikipedia.org/wiki/AMG-333
responsible for the sensation of cold |
https://en.wikipedia.org/wiki/TRPM8
increases the sensation of cold pain, also known as cold hyperalgesia |
|
https://en.wikipedia.org/wiki/TRPM8
improve cold tolerance |
|
Translocator protein (peripheral benzodiazepine receptor) |
|
TSPO |
https://en.wikipedia.org/wiki/DAA-1097
https://en.wikipedia.org/wiki/DAA-1106
https://en.wikipedia.org/wiki/Emapunil
anxiolytic |
https://en.wikipedia.org/wiki/Emapunil
anti-panic effects |
|
|
|
https://en.wikipedia.org/wiki/Emapunil
regulation of steroidogenesis, particularly the production of neuroactive steroids such as allopregnanolone in the brain |
|
insulin receptors |
|
metabolic insulin receptor B
(INSRB) |
|
|
|
|
insulin receptor A
(INSRA) |
|
|
insulin-like growth factor type 1 receptor
(IGF1R) |
|
|
insulin-like growth factor type 2 receptor
IGF-II |
|
|
Glycine |
|
GLRA1 |
|
|
https://en.wikipedia.org/wiki/Glycine_receptor,_alpha_1
hyperekplexia |
|
GLRA2 |
|
|
|
GLRA3 |
|
https://pubmed.ncbi.nlm.nih.gov/15131310/
(KO) lacked the inhibition of glycinergic neurotransmission by prostaglandin E2 seen in wildtype mice but also showed a reduction in pain sensitization induced by spinal prostaglandin E2 injection or peripheral inflammation |
|
GLRA4 |
https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=73
https://en.wikipedia.org/wiki/GLRA4
pseudogene in humans |
|
GLRB |
|
|
|
|
Purinergic receptor |
|
P2RX1 |
|
|
|
|
P2RX2 |
|
|
P2RX3 |
|
|
P2RX4 |
|
|
P2RX5 |
|
|
P2RX6 |
|
|
P2RX7 |
|
|
NPS suppresses anxiety and appetite, induces wakefulness and hyperactivity, including hyper-sexuality, and plays a significant role in the extinction of conditioned fear
https://en.wikipedia.org/wiki/Neuropeptide_S
Neuropeptide S receptor |
|
NPSR |
https://en.wikipedia.org/wiki/Neuropeptide_S_receptor
need less sleep time than normal ones. And resistant to memory impairment caused by lack of sleep. |
https://en.wikipedia.org/wiki/Neuropeptide_S_receptor
promotes arousal and anxiolytic-like effects |
|
|
|
|
|
https://en.wikipedia.org/wiki/DLG4
PSD-95 |
|
|
|
|
glucose |
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GLUT3 |
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|
|
|
substance p |
|
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anxiolaytic, works if you have pain, by inhibiting it (that's it!) |
|
Glycogen_synthase_kinase |
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GSK3A |
|
|
https://en.wikipedia.org/wiki/GSK3A
Twenty one tests were carried out on mutant mice but no significant abnormalities were observed |
|
GSK3B |
https://en.wikipedia.org/wiki/Glycogen_synthase_kinase-3_beta
bipolar disorder |
https://en.wikipedia.org/wiki/Glycogen_synthase_kinase-3_beta
inactivating agent of glycogen synthase |
|
https://en.wikipedia.org/wiki/Lithium_(medication)
Lithium inhibit it |
|
M-phase inducer phosphatase |
|
CDC25C |
https://en.wikipedia.org/wiki/CDC25C
This gene is highly conserved during evolution |
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cytokine |
Interleukin |
IL-2 |
|
|
|
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IL-1B |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560336/
accumulating evidence has indicated that IL-1β also adversely affects cognitive function (learning and memory) |
https://www.sciencedirect.com/science/article/abs/pii/S0889159103001405
High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β |
https://www.frontiersin.org/articles/10.3389/fnbeh.2017.00202/full
https://journals.sagepub.com/doi/10.1177/2398212820979802
may have a beneficial, temporary effect on learning and memory in young mice (dose depandant) |
|
|
https://pubmed.ncbi.nlm.nih.gov/21113196/
mediating inflammation and orchestrating the physiological and behavioral adjustments that occur during sickness |
https://www.sciencedirect.com/science/article/abs/pii/S0166432819300269
Memory consolidation impairment induced by Interleukin-1β (contextual memory) and a reduction in the total density of CA1 hippocampal dendritic spines |
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IL-1 |
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low-density lipoprotein |
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LDL-R |
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carrier protein |
fatty acids |
aP2/FABP4 |
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FABP4 effect on cognition
https://chat.openai.com/chat
when FABP4 was genetically deleted in mice, the animals exhibited improved spatial memory and increased neurogenesis (the production of new neurons)
FABP4 was overexpressed ,the mice showed impaired spatial memory and reduced neurogenesis.
FABP4 levels in the blood were negatively correlated with cognitive function in older adults. Specifically, higher levels of FABP4 were associated with poorer performance on tests of executive function and processing speed. |
|
Prostaglandin receptor |
Prostaglandin E2 receptor |
EP1 |
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kidney, kidney tubule, gastric mucosa, spleen, metanephric glomerulus, body of stomach, renal medulla, stromal cell of endometrium, fundus, upper lobe of left lung |
EP2 |
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monocyte, blood, bone marrow, bone marrow cells, canal of the cervix, gastric mucosa, cancellous bone, appendix, spleen, Achilles tendon |
EP3 |
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kidney tubule, kidney, renal medulla, myometrium, vena cava, adipose tissue, abdominal fat, subcutaneous adipose tissue, smooth muscle tissue, lower lobe of lung |
EP4 |
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palpebral conjunctiva, jejunal mucosa, glomerulus, metanephric glomerulus, bronchial epithelial cell, visceral pleura, synovial joint, germinal epithelium, parietal pleura, superficial temporal artery |
Prostaglandin DP |
DP1 |
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|
rectum, parietal pleura, germinal epithelium, trigeminal ganglion, blood, spleen, visceral pleura, Achilles tendon, right coronary artery, lymph node |
DP2 |
|
|
islet of Langerhans, body of stomach, monocyte, left ventricle, rectum, putamen, gastrocnemius muscle, prefrontal cortex, caudate nucleus, amygdala |
Prostaglandin F2α, Prostacyclin I2 receptor, Thromboxane A2 receptor |
FP |
|
|
Achilles tendon, gastric mucosa, tibial nerve, bronchial epithelial cell, synovial joint, smooth muscle tissue, stromal cell of endometrium, urethra, gallbladder, right coronary artery |
IP |
|
|
ascending aorta, right coronary artery, left coronary artery, upper lobe of left lung, monocyte, right lung, pericardium, vena cava, right lobe of thyroid gland, left lobe of thyroid gland |
TP |
|
|
olfactory bulb, popliteal artery, right coronary artery, ascending aorta, vena cava, left coronary artery, saphenous vein, pancreatic ductal cell, glomerulus, metanephric glomerulus |
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