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receptors concept db

July 23, 2019

 what is receptors function database:

info about what reaction will happen if you agonist/antagonist a receptor,

keep in your mind, the place of the receptor can make difference in receptor function, like agonizing adrenergic Ξ²2 receptor in the heart will cause fast heart beat and hypertension, between agonizing them in the brain will cause urge to fight, by increasing reward for violence behaviors..

add to that this is just self gathering info for multiple source, as of what i understand from experimenting, my info might be wrong, it's just will help you to know more about the general function of the receptor

advantages:

  • cell are colored for knowing its better to agonist the receptor or antagonist it
  • link for source are available (small button in the cell, laptop will be better to use)
  • endogenous and exogenous affinity to the receptors are available
  • always updated info because i search not to solve problems i search for searching.
  • free

color meaning
in ==> whats will happen if cells receptors cells
green suspected transporter
blue I'm sure better to agonist
red / better to be antagonist
violet / strong benefits in agonizing
black red / strong benefits in antagonizing
yellow just additional info /
auto-receptor the receptor that product negative feedback, mean it will decrease the release of it's endogenous neurotransmitter
anti-target pharmacy companies (eg, Eli Lilly) always make sure their drugs doesn't interact with that receptor because it cause problems

Neurotransmitters selectivity (Ki nm) receptor what's will happened if
expression pattrenn
endogenous exogenous agonized/enhanced
antagonized/inhibited
from wikipedia otherwise specified Top expressed in:
serotonin https://en.wikipedia.org/wiki/Serotonin /
SERT Serotonin reduction
increase serotonin https://watermark.silverchair.com/7-4-431.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAl0wggJZBgkqhkiG9w0BBwagggJKMIICRgIBADCCAj8GCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMhZ9AYpwW_aLxO8jUAgEQgIICENGNUKGcVAv3kyvEQ6j1fWo-e5VMr4DvIREwOlRoOfcq-0sA2VDH6fAPNCAHbZi_YAorxmboHSSZoyUW1uDkrCvvFioTBrETckPsr3wNzKJTBdL-yCLPQaZDeu9GYgZ83rGszWgKmgeP0sKjJmx5toTg4CNJEf5RdL-sCKTflH7qjnYER0rCWVJoJP3MOhKOqrtHxxGgrAJJG-UYnRMWjNSapFS41bB4BQIiiogV9ON0hUu20sS_5EuhVyMujVQbukhIsZtGquNY_g1oIiunrF0opBNPt99zaKzV_MBdk5sj0JVynAleKyCcIUOvN8eZNNrgR2A-QIO9JQkYHW6QD8nyIURKDhw0rj6_URc_B4QcxB7CjD8V-C6NLjVW9USUmoElPW9FpOumfrJ127-2W1ZA0LO8vJXXedOxcqtcokiwfRFFlT09xzqZ2D-UKrk3RkTqnjkiGK12nUSoJDNLW_WGEPCsYp4C_t65GvZSVYABqn42mgQgN6W3CRpvKcNhE29l7UcVP33_rWIgM-UF08XpUWNHboaS80w0eUE0FGQTvbLJebgANdWD7IzSQnHREyzZqPGZBLNXnz1-jdg9jYLfvZwxSD9su5pjZylhV_6k5vglQ4B307nP4fwouufDvMMaajWkN3Vnw7bGAt4ostQcDCEe9XmlvTnUqzqMSxuurcTC0rIzgFGmJLqzieD-Gw decrease D2 sensivity in striatal (sexual dysfunction, decrease drug seeking behaviors, anti gambling, anti Eating disorders, Akathisia , effect of ssris) which is known opposite effect of Dopamine 3 overactivity https://www.psychiatrist.com/JCP/article/Pages/double-blind-placebo-controlled-study-efficacy-safety-paroxetine-pathological-gambling.aspx https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_inhibitor https://en.wikipedia.org/wiki/Akathisia https://en.wikipedia.org/wiki/Impulse-control_disorder added to that empathy and restless leg syndrome of dopamine 3 blocking downregulate dopamine 3 receptors

https://en.wikipedia.org/wiki/Serotonin 1 HT1A https://en.wikipedia.org/wiki/Oxytocin and my exp increase ability to enjoy: love, empathy, talking and connection to others, bonding, trust, understanded, cuteness (there relation with oxytocin) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/figure/f1/ https://en.wikipedia.org/wiki/5-HT_receptor negative feedback https://en.wikipedia.org/wiki/5-HT_receptor Antidepressants (post-synaptic receptor agonists and pre-synaptic autoreceptor antagonists serve as antidepressants
https://en.wikipedia.org/wiki/5-HT_receptor depressant https://pubmed.ncbi.nlm.nih.gov/7905292/ reversed the sexual side effects of SSRIs
https://en.wikipedia.org/wiki/Serotonin 1.36 HT1B https://www.ncbi.nlm.nih.gov/pubmed/26423528 http://grantome.com/grant/NIH/R21-MH090555-02 induced repetitive behavior of ocd https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/figure/f1/ https://en.wikipedia.org/wiki/5-HT_receptor negative feedback
https://en.wikipedia.org/wiki/Serotonin aggression https://en.wikipedia.org/wiki/Isamoltane https://en.wikipedia.org/wiki/AR-A000002 https://en.wikipedia.org/wiki/SB-216641 anxiolytic https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2 https://pubmed.ncbi.nlm.nih.gov/25892302/ impulsivity and drug addiction (by increasing dopamine levels and dopamine release in the nucleus accumbens the place most expressed D3 receptors)
https://en.wikipedia.org/wiki/Serotonin 1.59 HT1D https://en.wikipedia.org/wiki/SB-699551 https://en.wikipedia.org/wiki/5-HT_receptor https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3 negative feedback https://en.wikipedia.org/wiki/Serotonin Vasoconstriction https://en.wikipedia.org/wiki/BRL-15572 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1565844/ inhibit/modulating release of glutamate
https://www.ncbi.nlm.nih.gov/pubmed/11313163 http://grantome.com/grant/NIH/R21-MH090555-02 antidepressant https://en.wikipedia.org/wiki/5-HT1D_receptor affects locomotion and anxiety "inhibits both dural vasodilation and inflammation" https://www.guidetopharmacology.org/GRAC/DatabaseSearchForward?searchString=HT1D&searchCategories=all&species=none&type=all&comments=includeComments&order=rank&submit=Search+Database inflammation
https://en.wikipedia.org/wiki/Serotonin 2.38 HT1E https://en.wikipedia.org/wiki/5-HT1E_receptor no info in the first 100 Google search result included https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=4 2020/12/18 might involved in the regulation of memory in humans
https://en.wikipedia.org/wiki/Serotonin 2.56 HT7 https://en.wikipedia.org/wiki/5-HT_receptor Autoreceptor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/ (external links used) https://en.wikipedia.org/wiki/Serotonin https://www.ncbi.nlm.nih.gov/pubmed/17869441 https://www.ncbi.nlm.nih.gov/pubmed/15755477 antidepressant & Cognition & ability to recognize old objects
>>https://en.wikipedia.org/wiki/Serotonin the main endogenous legend of 5-HT receptors, is a functionally selective agonist at this receptor, activating phospholipase C (which leads to inositol triphosphate accumulation), but does not activate phospholipase A2, which would result in arachidonic acid signaling >>https://en.wikipedia.org/wiki/Functional_selectivity 2.58 HT2C https://en.wikipedia.org/wiki/5-HT2C_receptor increase of corticotrophin releasing hormone (CRH) and vasopressin mRNA in the paraventricular nucleus and proopiomelanocortin in the anterior pituitary lobe. In rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/ https://www.ncbi.nlm.nih.gov/pubmed/27241709 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/ decrease impulsivity and motivation for drug and food https://en.wikipedia.org/wiki/5-HT2C_receptor https://en.wikipedia.org/wiki/PNU-22394 reduced cognitive deficits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/ anxiety: https://en.wikipedia.org/wiki/PNU-181731 anxiolytic or sometimes in some aspect anxiety https://en.wikipedia.org/wiki/5-HT2C_receptor estradiol and progesterone decrease the receptor concentration in the ventral hippocampus https://en.wikipedia.org/wiki/Atypical_antipsychotic increases release serotonin, norepinephrine and dopamine
https://en.wikipedia.org/wiki/Serotonin 2.75 HT2B https://en.wikipedia.org/wiki/Serotonin empathy https://en.wikipedia.org/wiki/5-HT2B_receptor Autoreceptor https://www.ncbi.nlm.nih.gov/pubmed/22158014 https://www.ncbi.nlm.nih.gov/pubmed/26727039 Required for behavioral effects of SSRIs https://en.wikipedia.org/wiki/Serotonin pulmonary hypertension


https://en.wikipedia.org/wiki/Serotonin 3.15 HT1F https://en.wikipedia.org/wiki/LY334370 treatment of migraine headaches https://en.wikipedia.org/wiki/LY334370 development was halted due to toxicity

https://en.wikipedia.org/wiki/Serotonin the main endogenous ligand of 5-HT receptors, is a functionally selective agonist at this receptor, activating phospholipase C (which leads to inositol triphosphate accumulation), but does not activate phospholipase A2, which would result in arachidonic acid signalling >>https://en.wikipedia.org/wiki/Functional_selectivity 3.64 HT2A https://en.wikipedia.org/wiki/Lysergic_acid_diethylamide hallucination https://en.wikipedia.org/wiki/5-HT2A_receptor anti-inflammatory inhibition: https://en.wikipedia.org/wiki/Atypical_antipsychotic promotion: https://en.wikipedia.org/wiki/5-HT2A_receptor inhibit dopamine release and increases in hormonal levels of oxytocin, prolactin, ACTH, corticosterone, and renin antidepressant https://en.wikipedia.org/wiki/Serotonin_syndrome Serotonin syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC446220/ antidepressant
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064746/ 5-HT2AR-mGluR2 complex is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
https://en.wikipedia.org/wiki/Serotonin 31 HT6 https://en.wikipedia.org/wiki/Serotonin https://en.wikipedia.org/wiki/WAY-208466 anti-anxiety https://www.ncbi.nlm.nih.gov/pubmed/20217056 https://en.wikipedia.org/wiki/Serotonin https://www.ncbi.nlm.nih.gov/pubmed/17428998 antidepressant https://www.ncbi.nlm.nih.gov/pubmed/17625499 increase GABA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/ Antagonists enhance
cognitive performance;
blockade of signaling is
anxiogenic 		https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706851/ https://www.ncbi.nlm.nih.gov/pubmed/16005519 reverse a scopolamine-induced cognitive deficit but it appears that 5-HT6 receptor blockade is more consistently effective in alleviating memory deficits than increasing memory in normally functioning animals https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706851/ Alzheimer's disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/ block effect of ssris
https://en.wikipedia.org/wiki/Serotonin 39.7 Author: HT4 https://en.wikipedia.org/wiki/Serotonin https://en.wikipedia.org/wiki/BIMU8 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/ Memory & learning + antidepressant effects https://ar.wikipedia.org/wiki/%D8%B3%D9%8A%D8%B3%D8%A7%D8%A8%D8%B1%D9%8A%D8%AF increase acetylcholine
https://en.wikipedia.org/wiki/GR-113808 respiratory depression
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=11 Modulation of dopaminergic neurotransmission.
https://en.wikipedia.org/wiki/Serotonin 79.2 HT5A https://en.wikipedia.org/wiki/Serotonin https://en.wikipedia.org/wiki/5-HT_receptor Auto receptor + Memory consolidation
https://en.wikipedia.org/wiki/Valerian_(herb) implicated in the sleep-wake cycle
https://en.wikipedia.org/wiki/Serotonin 187.1 HT3 Serotonin syndrome
https://en.wikipedia.org/wiki/Ondansetron Anti-vomiting https://en.wikipedia.org/wiki/Serotonin https://en.wikipedia.org/wiki/5-HT3_receptor anxiolysis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302148/ antidepressant
as of pspp ki database the dopamine affinity to its receptors is: DOPAMINE D4 0.999999969 DOPAMINE D3 9.677419355 Dopamine Transporter 10.80645161 DOPAMINE D4.4 11.61290323 DOPAMINE D1 20.96774194 DOPAMINE D2 Long 25.96774194 Dopamine D1A 35.48387097 DOPAMINE D5 36.77419355 Adrenergic Alpha 39.51612903 DOPAMINE D4.2 47.25806452 Norepinephrine transporter 52.09677419 DOPAMINE D2 59.19354839 TA1 68.06451613 5-HT1A 87.90322581 5-HT7 87.90322581 dopamine http://drugcentral.org/drugcard/947?q=Dopamine Wikipedia /
DAT dopamine reduction
increase dopamine
http://drugcentral.org/drugcard/947?q=Dopamine Wikipedia 1 found associations of ADHD ---------- associated with dyskinesia >>https://parkinsonsnewstoday.com/dopamine-agonists/ D1 https://en.wikipedia.org/wiki/Methylphenidate in prefrontal cortex : cognition-enhancing effects https://www.quora.com/Can-selective-full-dopamine-D1-agonists-like-Dihydrexidine-be-used-to-treat-ADHD hypotension https://www.quora.com/Can-selective-full-dopamine-D1-agonists-like-Dihydrexidine-be-used-to-treat-ADHD D1 receptors in the 'direct pathway' provide a range of possible decisions derived from activity in the cortex https://en.wikipedia.org/wiki/Ecopipam https://en.wikipedia.org/wiki/A-77636 https://en.wikipedia.org/wiki/Dopamine_receptor_D1 rewarded behaviors and pleasure, One such behavior is eating + nootropic, anorectic, rewarding and profound antiparkinson effects https://www.biologicalpsychiatryjournal.com/article/S0006-3223(09)01476-0/pdf#pageBody https://academic.oup.com/ijnp/article/23/5/287/5735643 goal directed behaviors (motivation)
https://en.wikipedia.org/wiki/Ecopipam anxiety and depression https://en.wikipedia.org/wiki/Dopamine_receptor_D1 effective antagonist d1(mostly the cause)/d5 product inhibition of acute euphoric effects of cocaine https://en.wikipedia.org/wiki/Ecopipam treatment of Tourette's syndrome
http://drugcentral.org/drugcard/947?q=Dopamine Wikipedia 1 The finding that the metabotropic glutamate receptor 2/3 (mGlu2/3) metabotropic glutamate receptor agonist, LY404039, improves clinical symptoms in schizophrenia (Patil et al., 2007) has stimulated a greater interest in the putative interactions between mGlu2/3 receptors and dopamine D2 receptors. A study using mGlu2 and mGlu3 receptor knockout mice has demonstrated that the proportion of D2 receptors in the striata is elevated by 220% and that there is a 67-fold and 17-fold increase in the sensitivity to a D2 agonist >>https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/metabotropic-glutamate-receptor-2 D2 https://www.quora.com/Can-selective-full-dopamine-D1-agonists-like-Dihydrexidine-be-used-to-treat-ADHD "increasing memory for complex tasks" >> https://en.wikipedia.org/wiki/Neuronal_calcium_sensor-1 D2 receptors in the 'indirect pathway' are activated to filter and select one of decisions provided by D1 receptor, add to that
increase reward for complex stuff like: internet, , programming, biohacking, high degree in sience and high ability to understand and use it, big dreams , urge/enjoyment to complete tasks perfectly (over activation if together with anxiety cause ocd) etc..
https://ar.wikipedia.org/wiki/%D9%85%D9%8A%D8%AA%D9%88%D9%83%D9%84%D9%88%D8%A8%D8%B1%D8%A7%D9%85%D9%8A%D8%AF Anti-vomiting https://en.wikipedia.org/wiki/Neuroleptic_malignant_syndrome Neuroleptic malignant syndrome https://en.wikipedia.org/wiki/Amisulpride antipsychotic positive symptoms "Pellegrino et al. and Franckx and Noel also reported domperidone-induced extrapyramidal symptoms especially dystonia" https://mansapublishers.com/IJCH/article/download/2331/1885/4876 extrapyramidal symptoms especially dystonia
hyperactivity and racing thought of adhd https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839459/ induce locomotion activity https://en.wikipedia.org/wiki/Dopamine_agonist "D2 receptor knockout mice exhibit hyperprolactinemia." https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=215 reduce prolactin increase capability to feel interested


D2s https://www.sciencedirect.com/topics/neuroscience/dopamine-autoreceptor negative feedback: reduce dopamine release and increase dopamine reuptake

http://drugcentral.org/drugcard/947?q=Dopamine Wikipedia 1 there an interact btw serotonin and D2 and D3 high serotonin inhibit them how D2, D3 inhibit serotonin why? SSRIs side effect: RLS, decrease sex, anti-ocd is known effect of blocking D2 and D3. D3 https://en.wikipedia.org/wiki/Ropinirole https://en.wikipedia.org/wiki/Pramipexole https://www.patientslikeme.com/treatment/5794-requip-xl-side-effects-and-efficacy?page=2# https://www.drugs.com/comments/cabergoline/for-hyperprolactinemia.html increase reward for: shopping, gambling, eating, drug seeking behaviors, Risk-Taking , impulsivity reward/urge to do recreactional activity https://en.wikipedia.org/wiki/Ropinirole https://en.wikipedia.org/wiki/Pramipexole anti-restless leg syndrome https://en.wikipedia.org/wiki/Dopamine_agonist reduce prolactin
https://ar.wikipedia.org/wiki/%D9%85%D9%8A%D8%AA%D9%88%D9%83%D9%84%D9%88%D8%A8%D8%B1%D8%A7%D9%85%D9%8A%D8%AF Anti-vomiting analyzed after seeing many interactions and lastly by this source https://en.wikipedia.org/wiki/Perphenazine block agitation induced by of D3 agonizing my expirience with halopiridol 8mg which is selective dopamine 3 antagonist and risporidone 12mg that cause clinicaly relevent antagonisting activity at dopamine 3 because its metabolism but after days of taking it and olanzpine 15mg which is selective at dopamine 2 and 3 and other dopamine receptors uncontrollable eye movement it like torture my experience with haloperidol (selective) respiridon (non selective)(high dose) fear from risk-taking stations
https://www.vox.com/2014/10/20/6995011/addiction-dopamine-agonist-parkinsons poriomania (A morbid impulse to wander or journey away from home.) increase enargy https://www.vox.com/2014/10/20/6995011/addiction-dopamine-agonist-parkinsons https://en.wikipedia.org/wiki/Impulse-control_disorder kleptomania (a recurrent urge to steal, typically without regard for need or profit.) increase capability to feel excited https://en.wikipedia.org/wiki/Impulse-control_disorder https://en.wikipedia.org/wiki/Dopamine_agonist Intermittent explosive disorder or IED is a clinical condition of experiencing recurrent aggressive episodes that are out of proportion of any given stressor.
as for partial agonists it's from bluelight but i forgot the actual link this link about abilify increase reward for sex https://www.bluelight.org/xf/threads/porn-addiction.908070/ abilify which is partial agonist cause risk avoidance and in the same time increase reward for sex https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=216 https://www.nature.com/articles/npp2012171.pdf?origin=ppub https://en.wikipedia.org/wiki/SB-277,011-A Blockade of the D3 receptor disrupts drug-associated cue-induced craving and stress-induced craving. my exp with multiple D3 antagonists longer attention span (solve short attention , D3 seems have great role in this)
https://www.vox.com/2014/10/20/6995011/addiction-dopamine-agonist-parkinsons increase libido and induce sexual fantasies https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=216 Stimulation of yawning tested by me in this drugs: halopiridol respiridon olanzpine anti-empathy effect https://en.wikipedia.org/wiki/Impulse-control_disorder https://en.wikipedia.org/wiki/Dopamine_agonist Pyromania: is characterized by impulsive and repetitive urges to deliberately start fires.

http://drugcentral.org/drugcard/947?q=Dopamine Wikipedia 1 found associations of ADHD no info in Wikipedia and very hard to get info in other source poorly understood D4 https://en.wikipedia.org/wiki/Dopamine_receptor_D4 https://en.wikipedia.org/wiki/Novelty_seeking Novelty seeking (increases the propensity for exploring to select a novel choice over familiar one (eg, human example in this is relationship cheating)) https://en.wikipedia.org/wiki/Dopamine_receptor_D4 increase working memory performance and fear "Craving novelty is definitely a thing we struggle with." https://www.reddit.com/r/ADHD/comments/qu43tc/comment/hkobqdu/?utm_source=reddit&utm_medium=web2x&context=3 "The harder I try to fall asleep the more impossible it becomes though lol Another issue I failed to mention is that this also includes relationships… before long they feel too routine and stale and I end it abruptly. Same with work too actually, I’ve quit a few jobs on a whim because I couldn’t stand the idea of doing it for one more day, not because I hated the job, but the whole routine of it." https://www.reddit.com/r/ADHD/comments/qu43tc/comment/hko6k7b/?utm_source=reddit&utm_medium=web2x&context=3 "Yes! It's almost like self sabotage. I hate routine with a passion." https://www.reddit.com/r/ADHD/comments/qu43tc/comment/hknx593/?utm_source=reddit&utm_medium=web2x&context=3 they thinking to switch routines "But then you switch it up, every x days starts a different routine." https://www.reddit.com/r/ADHD/comments/qu43tc/comment/hkoppxe/?utm_source=reddit&utm_medium=web2x&context=3 other argeement available in that (used) post in reddit. less productive by uability to stay i the same routien, this make you uable to stay in routine of work, because of novility seeking. https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00231 D4Rs expressed in PFC and hippocampus affect attention, exploratory behavior, (3) and performance in novel object recognition (4,5) and inhibitory avoidance (6) cognitive tasks
https://en.wikipedia.org/wiki/Dopamine_receptor_D4 https://pubmed.ncbi.nlm.nih.gov/10989267/ reverse stress-induced working memory deficits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994774/ https://www.longecity.org/forum/topic/100673-dopamine-agonists-pramipexolecabergoline-for-trdanhedonia/ https://www.bionews.org.uk/page_92722 associated with cheating, like in sex relationships and might other type of cheating too..


D4.7 https://en.wikipedia.org/wiki/Dopamine_receptor better cognitive performance
https://www.entrepreneur.com/living/there-is-a-wanderlust-gene-but-you-can-be-a-digital-nomad/311322 cause a strong desire, if not impulse, to wander, travel and explore the world.


novelty seeking is wide rang of behavior characterized by curiosity, adventure, exploration urges, backed by their rewards which is mediated by dope 4 receptors

was no info in >>http://drugcentral.org/drugcard/947?q=Dopamine >>Wikipedia but now without links i forget some info about it being x10 of D1 x10 of D1 found associations of ADHD ---------- associated with dyskinesia >>https://parkinsonsnewstoday.com/dopamine-agonists/ D5 https://en.wikipedia.org/wiki/Brain-derived_neurotrophic_factor Activation of Dopamine receptor D5 promotes expression of BDNF in prefrontal cortex neurons
https://en.wikipedia.org/wiki/Dopamine_receptor_D5 reduces burst firing and improve motor deficits, increased motor response to administration of methamphetamine https://en.wikipedia.org/wiki/Dopamine_receptor_D5 learning problems (fear memory aid by B2 and M1 receptors) that may be associated with ADHD https://en.wikipedia.org/wiki/Dopamine_receptor_D5 hypertension
going away from sad behaviors Noradrenaline http://drugcentral.org/drugcard/1960 /
NET noradrenalin reduction
increase noradrenalin
http://drugcentral.org/drugcard/1960 / α1 https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor vasoconstriction https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor anorexia https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor inhibit hearing system
https://en.wikipedia.org/wiki/Antihypertensive_drug https://en.wikipedia.org/wiki/Alpha_blocker https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor orthostatic hypotension https://en.wikipedia.org/wiki/Silodosin inhibit ejaculation but not orgasm
http://drugcentral.org/drugcard/1960 1.2409381663113 α1A https://en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor inhibit olfactory system

http://drugcentral.org/drugcard/1960 1 α1B no info in Wikipedia

http://drugcentral.org/drugcard/1960 / α1C

http://drugcentral.org/drugcard/1960 1.57782515991471 α1D

http://drugcentral.org/drugcard/1960 / α2 https://en.wikipedia.org/wiki/Alpha_blocker vasoconstriction https://en.wikipedia.org/wiki/Clonidine anti ptsd + anxiety disorders


http://drugcentral.org/drugcard/1960 1.53091684434968 α2A https://en.wikipedia.org/wiki/Guanfacine https://en.wikipedia.org/wiki/Antihypertensive_drug https://en.wikipedia.org/wiki/Clonidine https://en.wikipedia.org/wiki/Methylphenidate in prefrontal cortex : cognition-enhancing effects + lowering blood pressure https://en.wikipedia.org/wiki/Alpha-2C_adrenergic_receptor negative feedback: at high stimulation frequencies

http://drugcentral.org/drugcard/1960 1.3816631130064 α2B https://en.wikipedia.org/wiki/Alpha-2B_adrenergic_receptor emotional memory focus more on negative aspects of a situation

http://drugcentral.org/drugcard/1960 1.53518123667377 α2C https://en.wikipedia.org/wiki/Alpha-2C_adrenergic_receptor negative feedback : at lower levels of nerve activity

http://drugcentral.org/drugcard/1960 1.28 β1 https://en.wikipedia.org/wiki/Beta-1_adrenergic_receptor https://en.wikipedia.org/wiki/Metoprolol anxiolytic https://en.wikipedia.org/wiki/Denopamine https://en.wikipedia.org/wiki/Dobutamine https://en.wikipedia.org/wiki/Xamoterol https://en.wikipedia.org/wiki/Metoprolol treatment of slow heart rate https://en.wikipedia.org/wiki/Autoreceptor in (SNS) positive feedback
https://academic.oup.com/sleep/article/44/Supplement_2/A154/6260529 https://www.malacards.org/card/short_sleep_familial_natural_2 https://pubmed.ncbi.nlm.nih.gov/31473062 https://pubmed.ncbi.nlm.nih.gov/10335905/ https://you.com/search?q=give me detailed report about ADRB1 receptors effect on sleep&tbm=youchat&cfr=chat .then(more in depth) .then(can you give me all source links for this info) [1] https://news.uchicago.edu/story/gene-causes-people-sleep-less-six-and-half-hours-night [2] https://www.sleepfoundation.org/sleep-news/new-short-sleep-gene-discovered [3] https://www.huffpost.com/entry/sleep-genes-the-key-to-getting-the-best-sleep-possible_l_5d6f04b6e4b0f8b6c2d6de0e [4] https://www.sleep.org/articles/natural-short-sleepers/ [5] https://www.nih.gov/news-events/news-releases/mutation-1-adrenergic-receptor-affects-sleepwake-behaviors [6] https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRB1 [7] https://www.fda.gov/home [8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905629/ [9] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449478/ [10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795613/ Short sleeper syndrome (short sleep familial natural 2)

highly expressed in the dorsal pons and that these ADRB1+ neurons are active during rapid eye movement (REM) sleep causing wakefullness

decrease melatonin release

mutatuion =
higher levels of alertness during wakefulness
greater sensitivity to cold temperatures (which may explain why natural short sleepers (NSS) need less sleep than the average person)
have been found to accumulate more sleep pressure, likely due to their shorter sleep in the dark phase (ibti consilation= melatonin inhibition)

https://en.wikipedia.org/wiki/Betaxolol https://en.wikipedia.org/wiki/Bisoprolol https://en.wikipedia.org/wiki/Norepinephrine https://en.wikipedia.org/wiki/Nebivolol treatment of hypertension and glaucoma https://en.wikipedia.org/wiki/Nebivolol bronchoconstriction (less affective then β2) https://en.wikipedia.org/wiki/Nebivolol selectively block β1 adrenergic receptors reduced typical beta-blocker-related side effects, such as fatigue, clinical depression, bradycardia, or impotence
http://drugcentral.org/drugcard/1960 1.14712153518124 β2 https://en.wikipedia.org/wiki/Adrenergic_receptor increase rewards for: fighting, listening rap music, social dominance https://www.nature.com/articles/npp2016238 edition: β-AR activation increases the expression of the a-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor subunit GluA1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086548/ NE also increases memory consolidation through an increase in glucose availability https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086548/ The mRNA levels for GLUT3, a glucose transporter expressed in the central nervous system, were significantly reduced in the amygdala, but not in the hippocampus of the β3-ARKO animals https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086548/ increased breakdown of glycogen by phosphorylase glycogen brain (PYGB) activation in response to β2-AR activation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086548/ while β3-AR mediates the glucose uptake by the glucose transporter type 3 (GLUT3). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086548/ βARs modulates aversive memory formation following PTC (Pavlovian threat [fear] conditioning) by initiates the activation of two plasticity-related targets: AMPA receptors (AMPARs) for associations memory acquisition to short-term memory and extracellular regulated kinase (ERK) for consolidating the learned association into a long-term memory
https://en.wikipedia.org/wiki/Atenolol depression https://en.wikipedia.org/wiki/Nebivolol bronchoconstriction
my experience with terbutaline nervous and excitable, increase respiration speed, fine visual Hallucinations, rather not to say empathy talk

http://drugcentral.org/drugcard/1960 1.14498933901919 β3 https://en.wikipedia.org/wiki/Adrenergic_receptor tremors https://en.wikipedia.org/wiki/Amibegron antidepressant and anxiolytic


https://en.wikipedia.org/wiki/Mirabegron https://en.wikipedia.org/wiki/Solabegron https://en.wikipedia.org/wiki/Vibegron treat overactive bladder https://en.wikipedia.org/wiki/Beta-3_adrenergic_receptor https://examine.com/supplements/oleoylethanolamide/research/#Yl1DjJP-neurology_Yl1DjJP-miscellaneous-mechanisms induce fat breaking in adipose tissue / anti muscle stress effects

encourages a reduction in food intake


histamine PSPP 102.92
H1 https://pubmed.ncbi.nlm.nih.gov/18845973/ orthostatic hypotension https://en.wikipedia.org/wiki/Histamine Sleep-wake cycle (promotes wakefulness), body temperature, nociception, endocrine homeostasis, regulates appetite, involved in cognition
https://en.wikipedia.org/wiki/Antihistamine anti-sensitivity https://en.wikipedia.org/wiki/Antihistamine anti-insomnia https://en.wikipedia.org/wiki/Antihistamine anti-acne dizziness
you.com Tuberomammillary_nucleus, Pars_reticulata
PSPP 15.848931924611 H2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698467/ https://link.springer.com/article/10.1007/BF00432550 promote aggression
https://en.wikipedia.org/wiki/Antihistamine The ulcer https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.20015#:~:text=studies%2C%20histamine%20and%20stimulation%20of,effects%20of%20histamine%20on%20waking. stimulation of the histamine H1 receptor (H1R) or blockade of the histamine H2 receptor (H2R) increase measures of anxiety https://www.scielo.br/j/bjmbr/a/pgwjTqDJmsqG8c7TVbbrpQR/?format=pdf&lang=en impairment of memory consolidation
PSPP 6.78 H3 https://en.wikipedia.org/wiki/Histamine_H3_receptor autoreceptors
https://en.wikipedia.org/wiki/Betahistine anti-vertigo https://en.wikipedia.org/wiki/Betahistine increase histamine, acetylcholine, norepinephrine, serotonin, GABA release https://en.wikipedia.org/wiki/Ciproxifan stimulant + wakefulness + cognitive enhancing at relatively low levels of receptor occupancy https://en.wikipedia.org/wiki/Thioperamide improve memory consolidation


side effects include difficulty sleeping, nausea, and feeling worried treatment of excessive daytime sleepiness in adults with narcolepsy.[2] It is a histamine 3 (H3) receptor antagonist/inverse agonist >>https://en.m.wikipedia.org/wiki/Pitolisant >>my exp with betahistine he was diminishing the uncaring of lamotrigine Histamine H1 receptor antagonists and H3 receptor agonists decrease the anxiety state https://pubmed.ncbi.nlm.nih.gov/10917464/ more avidance of awakeing based anxiety https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.20015#:~:text=studies%2C%20histamine%20and%20stimulation%20of,effects%20of%20histamine%20on%20waking. increase wakefulness and partially cognition by increasing ability to feeling worried, personally i called it awwerness, seems more accurate word
PSPP 17.1 H4

https://en.wikipedia.org/wiki/Histamine_H4_receptor https://en.wikipedia.org/wiki/JNJ-7777120 https://en.wikipedia.org/wiki/VUF-6002 anti-inflammatory and antihyperalgesic effects
in kidatabase used: HUMAN Chick RAT acetylcholine Muscarinic

asyt T

increase acetylcholine

1 M1 https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1 https://en.wikipedia.org/wiki/Hyoscine Secretion from salivary glands https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1 aggression https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1 https://en.wikipedia.org/wiki/Telenzepine Secretion from salivary glands https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1 https://en.wikipedia.org/wiki/Pirenzepine Gastric acid secretion from stomach and muscle spasm. https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1 olfactory behaviors (e.g. mating is the pairing of either opposite-sex or hermaphroditic organisms )
https://en.wikipedia.org/wiki/Hyoscine inhibit ability of recall memory https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M1 Delirium hallucinations agonisting cause anxiety-like behaviour >https://pubmed.ncbi.nlm.nih.gov/11374337/ anxiolytic

>>https://pubmed.ncbi.nlm.nih.gov/11374337/ disrupt spontaneous working memory

100.882352941176 M2 https://en.wikipedia.org/wiki/Autoreceptor https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M4 https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M2 negative feedback https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M2 slow the heart rate
https://en.wikipedia.org/wiki/Methoctramine Responsible for decrease in sexual activity, as a study using rats confirmed

https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M2 Mediating olfactory guided behaviors (e.g. odor discrimination, aggression, mating).[10]
235.294117647059 M5 https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=17 Stimulation of gastric acid secretion. https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=17 increase dopamine release
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=17 M5 receptor knockout mice exhibit a reduction in the reinforcing effects and withdrawal symptoms of cocaine and morphine
corpus callosum, substantia nigra, hypothalamus, inferior ganglion of vagus nerve, placenta, prefrontal cortex, right lobe of liver, pharynx, Brodmann area 9, hippocampus proper

M4 https://en.wikipedia.org/wiki/Clozapine hypersalivation https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M4 https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor inhibit D1-induced locomotion stimulation https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=16 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369681/ Inhibition of dopaminergic (D1 receptor) signaling https://en.wikipedia.org/wiki/Autoreceptor https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M4 negative feedback
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=16 treatment of Parkinson's disease https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=16 knockout mice exhibit an increase in anxiolysis compared to wild-type mice

M3 https://en.wikipedia.org/wiki/Muscarinic_acetylcholine_receptor_M3 increased secretions from stomach (emesis)
https://en.wikipedia.org/wiki/Pimozide change glucose to weight gain (olanzpine)+diabetes side-effects https://en.wikipedia.org/wiki/Darifenacin decreases the urgency to urinate https://www.atsjournals.org/doi/full/10.1513/pats.200504-038SR anti-asthma
nicotinic

α1 no info in the first 100 Google search result
α2 http://learnmem.cshlp.org/content/24/6/231.full https://en.wikipedia.org/wiki/CHRNA2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831006/ influence hippocampus-dependent learning and memory and behaviors
α3

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=464&familyId=76&familyType=IC Heterozygous α3 mice are less sensitive to nicotine-induced seizures.
α4 https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=465&familyId=76&familyType=IC induced release of dopamine
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=465&familyId=76&familyType=IC more sensitive to nicotine-induced hypothermia and nicotine-induced seizures and sleep disruptions https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=465&familyId=76&familyType=IC altered nicotinic modulation of respiratory rhythm
α5

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=466&familyId=76&familyType=IC Knockout mice show increased nicotine intake in self-administration tests, Reduced sensitivity to nicotine-induced behavioral effects and seizures, Increased attentional performance
22.35 7,75 (nicotine) α6 https://www.ncbi.nlm.nih.gov/pubmed/23594044 https://en.wikipedia.org/wiki/CHRNA6 increase reward and reinforcing effects



103 (nicotine) α7 https://en.wikipedia.org/wiki/Nicotinic_acetylcholine_receptor some of the cognitive effects of nicotine



α8 no info in the first 100 Google search result
α9
α10 https://www.google.com/search?client=firefox-b-d&q=nicotinic+acetylcholine+receptor+%CE%B110+subunit no info in the first 100 Google search result
β1 https://www.ncbi.nlm.nih.gov/pubmed/28153524 https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=471&familyId=76&familyType=IC expressed in vertebrate skeletal muscle and placenta
β2 https://www.ncbi.nlm.nih.gov/pubmed/21836018 increase attentional performance
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=472&familyId=76&familyType=IC Knockout mice loss of nicotine-induced dopamine and GABA release, impaired development of the visual system, increased passive avoidance latency; loss of nicotine self-administration, reduced nicotine-induced antinociception, impaired learning and increased neurodegeneration in aged animals
β3 https://www.ncbi.nlm.nih.gov/pubmed/31145916 chronic exposure induced withdrawal https://f1000.com/prime/725756334 https://www.sciencedirect.com/science/article/abs/pii/S0028390815300800 https://en.wikipedia.org/wiki/CHRNB3 https://www.ncbi.nlm.nih.gov/pubmed/26318101 Modulation of gene expression and increase nicotine consumption https://www.jneurosci.org/content/23/35/11045 Modulate Dopamine Release
https://www.ncbi.nlm.nih.gov/pubmed/31145916 hyperalgesia, anhedonia-like effect
β4

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=474&familyId=76&familyType=IC Knockout mice display decreased anxiety-related responses; resistance to nicotine-induced seizures; decreased nicotine withdrawal https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869047/ Nicotine intravenous self-administration (IVSA) was lower in constitutive β4 knockout (KO) mice at all doses tested, β4KO mice have higher extracellular dopamine (DA) levels in the nucleus accumbens
γ https://www.ncbi.nlm.nih.gov/pubmed/7684117 expressed in adult extraocular muscle and involvement in myasthenia gravis
δ https://www.google.com/search?client=firefox-b-d&q=nicotinic+acetylcholine+receptor+%CE%B4+subunit no info in the first 100 Google search result
ε

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=477&familyId=76&familyType=IC knockout mice display impaired neuromuscular transmission, progressive muscle weakness and atrophy and associated with the human AChR deficiency syndrome
3.04 1 (nicotine) α4β2 https://en.wikipedia.org/wiki/Nicotine improvements in attentional performance https://en.wikipedia.org/wiki/Varenicline release of dopamine in the nucleus accumbens


2.24 1,38 (nicotine) α2β2


16.47 3,48 (nicotine) α3β2

23.09 8,68 (nicotine) α4β4

32.35 23,5 (nicotine) α2β4

21.18 37,9 (nicotine) α6β4

36.18 50,7 (nicotine) α6β2


60,4 (nicotine) α6β3β4α5

230.29 92,9 (nicotine) α3β4
https://en.wikipedia.org/wiki/18-Methoxycoronaridine https://en.wikipedia.org/wiki/18-Methylaminocoronaridine anti-addiction
Sigma σ1 https://en.wikipedia.org/wiki/Sigma_receptor hallucinogenic https://en.wikipedia.org/wiki/Sigma_receptor https://en.wikipedia.org/wiki/PRE-084 nootropic and antidepressant actions in animal studies, as well as antitussive https://en.wikipedia.org/wiki/Cutamesine anti-amnesic
https://en.wikipedia.org/wiki/Sigma_receptor antipsychotic https://en.wikipedia.org/wiki/LR132 https://en.wikipedia.org/wiki/BD1063 decreases the convulsivity
σ2 https://en.wikipedia.org/wiki/Sigma-2_receptor no role in depression https://en.wikipedia.org/wiki/Sigma-2_receptor regulate cholesterol transporter NPC1, involved in cholesterol homeostasis


glutamate transporter
EAAT1



EAAT2 https://en.wikipedia.org/wiki/Excitatory_amino_acid_transporter_2 induce/enhance the expression of EAAT2=reduce the development and expression of tolerance to opiates and other drugs of abuse
https://en.wikipedia.org/wiki/Excitatory_amino_acid_transporter_2 https://en.wikipedia.org/wiki/Acetylcysteine reduced expression of EAAT2= increase addictive/drug-seeking behavior and increase in vulnerability to relapse after re-exposure to the addictive drug or its associated drug cues
EAAT3 https://en.wikipedia.org/wiki/Excitatory_amino_acid_transporter_3 mice lacking EAAT3 exhibit reduced levels of glutathione in neurons, increased oxidative stress, and age-dependent loss of neurons, especially neurons of the substantia nigra. A meta-analysis identified a small but significant association between a polymorphism of the gene SLC1A1 and Obsessive-Compulsive Disorder
EAAT4 https://en.wikipedia.org/wiki/Excitatory_amino_acid_transporter_4 see Cerebellumfunction here https://en.wikipedia.org/wiki/Cerebellum expressed predominantly in the cerebellum
EAAT5 https://en.wikipedia.org/wiki/Excitatory_amino_acid_transporter_5 predominantly in the retina
VGLUT1

VGLUT2
VGLUT3 https://en.wikipedia.org/wiki/Vesicular_glutamate_transporter_3 https://en.wikipedia.org/wiki/Glutamate_transporter#VGLUTs transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft
Mutations in this gene are the cause of autosomal-dominant nonsyndromic deafness
modulatory in auditory system
it modulates a wide range of neuronal and physiological processes like anxiety, mood regulation, impulsivity, aggressive behavior, pain perception, sleep–wake cycle, appetite, body temperature and sexual behavior. Certainly, no significant change was found in aggression and depression-like behaviors, but in contrast, the loss of VGluT3 resulted in a specific anxiety-related phenotype.
NR2B=GluN2B etc.. A 1990 study found an NMDA receptor antagonist, taken concurrently with a benzodiazepine completely eliminated tolerance, dependence, and ultimately withdrawal when use was stopped, on mice or rat. But when NMDA receptor antagonist was used only during withdrawal periods, it had no effect. Whereas an AMPA antagonist nearly eliminated withdrawal during the withdrawal period, but had no effect when taken concurrently, I.e the opposite of the findings of NMDA antagonist. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC47038/ Benzo withdrawal is regarded as very uncomfortable and dangerous, yet no one I’ve interacted with has heard of this or uses it in practice. https://www.reddit.com/r/DrugNerds/comments/9s1vw5/comment/e8mdzyo/?utm_source=reddit&utm_medium=web2x&context=3 NMDA
NR1 (glycine) https://en.wikipedia.org/wiki/GRIN1 plasticity of synapses which is believed to underlie memory and learning


https://www.reddit.com/r/researchchemicals/comments/eqcqjb/ha966_an_atypical_sedative_anybody_have_any/ https://en.wikipedia.org/wiki/HA-966 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824088/ anxiolytic (emotional blunting not disinhibition), sedative, dissociative feeling (altered state), Reduces pain sensitivity, neuroprotective, distorts visual acuity https://en.wikipedia.org/wiki/Apimostinel https://en.wikipedia.org/wiki/Rapastinel https://en.wikipedia.org/wiki/Apimostinel antidepressant
NR2A http://www.jneurosci.org/content/early/2018/03/28/JNEUROSCI.0394-18.2018 increase long term pentination https://knowingneurons.com/2013/01/28/brain-changes-for-sculpted-efficient-memory/ short-term memory


NR2B (glutamate) https://knowingneurons.com/2013/01/28/brain-changes-for-sculpted-efficient-memory/ long-term memories
https://en.wikipedia.org/wiki/Traxoprodil https://en.wikipedia.org/wiki/Rislenemdaz neuroprotective, analgesic, and anti-Parkinsonian and ketamine-like rapidly-acting antidepressant and dissociative https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824088/ reduce anxiety
NR2C https://en.wikipedia.org/wiki/GRIN2C no info
NR2D https://en.wikipedia.org/wiki/GRIN2D long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning
NMDA

https://en.wikipedia.org/wiki/NMDA_receptor_antagonist antidepressant >>https://www.quora.com/Can-NMDA-receptor-antagonists-like-ketamine-and-the-arylcyclohexylamines-produce-memory-problems-possibly-permanent its problem with kitamin and MXE too see >>https://www.bluelight.org/xf/threads/receptors-function-database.882003/post-14700487 forget links: in reddit for some one took 2000mg DXM lead to bladder issues bladder issues
channel (eg, MK-801)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278809/ attenuate drug cue associations
NR3A


NR3B
https://you.com/search?q=gene+linked+to+Depersonalization-derealization+disorder&fromSearchBar=true&tbm=youchat https://www.malacards.org/card/depersonalization_disorder An important gene associated with Depersonalization Disorder is GRIN3B (Glutamate Ionotropic Receptor NMDA Type Subunit 3B). Studies have suggested that this gene may be linked to the development of depersonalization symptoms [1][2]. Additionally, there have also been studies that suggest an association between stress-linked genes and derealization and depersonalization symptoms.
NRL1A


NRL1B

AMPA
AMPA https://en.wikipedia.org/wiki/Tulrampator https://en.wikipedia.org/wiki/Sunifiram motor coordination disruptions, convulsions, and neurotoxicity, enhance cognition and memory, to produce antidepressant-, antianhedonic-, and anxiolytic-like effects, and to have neurotrophic and neuroplasticity-promoting activities. increase levels of BDNF in the hippocampus and to stimulate hippocampal neurogenesis https://en.wikipedia.org/wiki/AMPA_receptor_positive_allosteric_modulator high-impact AMPAR PAMs decrease both deactivation and desensitization together to enhance and prolong synaptic currents https://en.wikipedia.org/wiki/Tulrampator rapidly-acting antidepressant effects of the NMDA receptor antagonist ketamine appear to be mediated through indirect/downstream activation of AMPARs https://en.wikipedia.org/wiki/Tulrampator antidepressant-like effects in animals are blocked by the AMPAR antagonist NBQX
https://en.wikipedia.org/wiki/Becampanel anticonvulsant https://en.wikipedia.org/wiki/Dasolampanel https://en.wikipedia.org/wiki/Becampanel https://en.wikipedia.org/wiki/Selurampanel neuropathic pain https://en.wikipedia.org/wiki/Fanapanel sedation
GRIA1 https://en.wikipedia.org/wiki/GRIA1 centrally involved in synaptic plasticity. Expression of the GluR1 gene is significantly reduced in the human frontal cortex with increasing age
GRIA2 https://www.ncbi.nlm.nih.gov/pubmed/21248105 regulation of AMPA receptor properties and synaptic plasticity/regulates metabotropic glutamate receptor-dependent long-term depression
GRIA3 https://en.wikipedia.org/wiki/GRIA3 https://en.wikipedia.org/wiki/GRIA4 RNA editing allow faster recovery from desensitization therefore allows continue response to stimulant
GRIA4
Kainate
KA1/GluR5 https://en.wikipedia.org/wiki/GRIK4 regulation of antidepressant treatment-response like citalopram


https://www.ncbi.nlm.nih.gov/pubmed/12724156 protect against seizures https://en.wikipedia.org/wiki/Tezampanel neuroprotective + anticonvulsant + antihyperalgesic + analgesic + anxiolytic https://en.wikipedia.org/wiki/Tezampanel suppresses both the withdrawal symptoms from opioids and the development of tolerance
KA2/GluR6
https://en.wikipedia.org/wiki/GRIK2 associated with nonsyndromic autosomal recessive mental retardation https://www.ncbi.nlm.nih.gov/pubmed/18332879 GluR6 KO mice exhibited less anxious or more risk-taking type behavior and less despair-type manifestations, and they also had more aggressive displays
KA3/GluR7 https://en.wikipedia.org/wiki/GRIK3 RNA editing
KA4



KA5

Metabotropic
glutamate
receptor
mGluR5 https://en.wikipedia.org/wiki/ADX-47273 nootropic and antipsychotic effects
https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_5 https://en.wikipedia.org/wiki/3-((2-Methyl-4-thiazolyl)ethynyl)pyridine https://en.wikipedia.org/wiki/Fenobam reduce drug self-administration regardless of dose https://en.wikipedia.org/wiki/Lithium_(medication) learned helplessness
mGluR3 https://en.wikipedia.org/wiki/LY-379,268 sedative, neuroprotective, anti-addictive and anticonvulsant
https://en.wikipedia.org/wiki/Eglumegad anxiolytic effects without producing sedation + slightly reduce cognitive performance + inhibiting the development of tolerance to morphine + relieving the symptoms of withdrawal from chronic use of both nicotine and morphine + reducing the effects of 5HT2A agonist hallucinogens + noticable reduce of yohimbine-induced stress response
https://en.wikipedia.org/wiki/RO4491533 antidepressant https://en.wikipedia.org/wiki/LY-341,495 antidepressant
increase behavioral effects of hallucinogenic drugs
increasing analgesic effects of μ-opioid agonists
modulating dopamine receptor function		 https://en.wikipedia.org/wiki/MGS-0039 antagonizing give anxiolytic effect too but its deferent then the anxiolytic effect produced by agonists https://en.wikipedia.org/wiki/MGS-0039 antidepressant and anxiolytic + boost release of dopamine and serotonin in specific brain areas
mGluR2 https://en.wikipedia.org/wiki/LY-487,379 https://en.wikipedia.org/wiki/ADX-71149 antipsychotic and anxiolytic https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_2 auto receptor https://en.wikipedia.org/wiki/Biphenylindanone_A decreases cocaine self-administration in rats, with no effect on food self-administration

mGluR1

https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_1 block adrenergic receptor activation in neurons https://www.ncbi.nlm.nih.gov/pubmed/18164695 neuroprotective agent for the treatment of stroke. https://www.ncbi.nlm.nih.gov/pubmed/17597604 analgesic https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_1 Mice lacking mGluR1 had impaired motor functions, characterized by impaired balance. In the Morris watermaze test, an assay for learning abilities, those mice needed significantly more time to successfully complete the task
mGluR1a
https://www.jneurosci.org/content/35/38/13110 significantly inhibited sexual motivation
mGluR4 https://en.wikipedia.org/wiki/Foliglurax https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_4 https://en.wikipedia.org/wiki/PHCCC treatment of Parkinson's disease


mGluR7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923231/ inhibit cocaine and alcohol self-administration

mGluR8 https://en.wikipedia.org/wiki/DCPG anticonvulsant + treatment for hyperalgesia

mGluR6 https://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor_6 response to light
Orphan
GluD1



GRID2

GABA
α https://en.wikipedia.org/wiki/GABA_receptor_agonist sedative + relaxing
https://www.ncbi.nlm.nih.gov/pubmed/20655491 antidepressant https://en.wikipedia.org/wiki/GABA_receptor_antagonist stimulant
α1 https://en.wikipedia.org/wiki/Zolpidem induce sleep https://en.wikipedia.org/wiki/L-838,417 sedative or amnestic


α2
https://en.wikipedia.org/wiki/%CE%915IA https://en.wikipedia.org/wiki/L-838,417 anxiolytic

α3 https://en.wikipedia.org/wiki/GABRA3 anxiolytic effects without sedative, amnesia, or ataxia.

α4 https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=407 amnesia https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=407 ataxic, sedative, and analgesic effects
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=407 decreases their free consumption of and preference for alcohol
α5

https://en.wikipedia.org/wiki/GABAA_receptor_negative_allosteric_modulator do not have convulsant or anxiogenic effects but instead show cognitive- and memory-enhancing or nootropic-like effects
α6


β https://en.wikipedia.org/wiki/GABA_receptor_agonist sedative + relaxing
https://www.ncbi.nlm.nih.gov/pubmed/20655491 antidepressant https://en.wikipedia.org/wiki/GABA_receptor_antagonist stimulant
β1 https://en.wikipedia.org/wiki/Lesogaberan agonist anticipated to have fewer of the central nervous system side effects that limit the clinical use of baclofen for the treatment of gastroesophageal reflux disease ,
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=240 KO show lack of muscle relaxation
β2 https://en.wikipedia.org/wiki/Etomidate anesthetic


β3 https://en.wikipedia.org/wiki/Etomidate sedation

α-ρ1 no info at all
ascending aorta, pancreatic ductal cell , tibialis anterior muscle ,deltoid muscle ,left coronary artery ,testicle ,right coronary artery ,placenta ,gastrocnemius muscle ,lower lobe of lung
α-ρ2 https://en.wikipedia.org/wiki/Etifoxine SSRIs like effect https://ar.wikipedia.org/wiki/%D8%A5%D9%8A%D8%AA%D9%8A%D9%81%D9%88%D9%83%D8%B3%D9%8A%D9%86 increase serotonin



α-ρ3

γ1


γ2
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=414&familyId=72&familyType=IC elevated anxiety + altered emotional behavior reminiscent of melancholic depression + depression related anhedonia in the sucrose consumption test https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=414&familyId=72&familyType=IC elevated serum corticosterone levels https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=414&familyId=72&familyType=IC epilepsy
γ3 https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=415&familyId=72&familyType=IC Autism and autism spectrum disorders
δ

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=416&familyId=72&familyType=IC Knockout females, but not males, show improved fear conditioning https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=416&familyId=72&familyType=IC Mice lacking the δ subunit show reduced sensitivity to neuroactive steroids
ε


θ

π https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=419&familyId=72&familyType=IC overexpressed in pancreatic adenocarcinomas

opioid
DOR δ1 https://en.wikipedia.org/wiki/Opioid_receptor euphoria https://en.wikipedia.org/wiki/Opioid_receptor physical dependence https://en.wikipedia.org/wiki/SNC-80 https://en.wikipedia.org/wiki/DPI-287 https://en.wikipedia.org/wiki/Opioid_receptor analgesic, antidepressant and anxiolytic effects in animal studies, but its usefulness is limited by producing convulsions at high doses

DOR δ2

KOR κ1 https://en.wikipedia.org/wiki/Opioid_receptor https://www.bluelight.org/xf/threads/receptors-function-database.882003/post-14700487 analgesic, anxiogenic https://en.wikipedia.org/wiki/%CE%9A-opioid_receptor suppress itching https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=318 stimulation of prolactin release

antidepressent
KOR κ2 https://www.jneurosci.org/content/jneuro/14/9/5580.full.pdf Inhibit NMDA Receptor-mediated Synaptic
Currents (dissociative hallucinations)

KOR κ3


MOR μ1 https://en.wikipedia.org/wiki/Opioid_receptor respiratory depression https://en.wikipedia.org/wiki/Opioid_receptor physical dependence https://en.wikipedia.org/wiki/Opioid_receptor analgesia https://www.hcplive.com/view/testosterone-deficiency-a-side-effect-of-opioids https://link.springer.com/article/10.1007/s40618-018-0964-3 https://en.wikipedia.org/wiki/Opioid-induced_endocrinopathy Opioids down-regulate the HPA-axis to produce near-castrate testosterone levels, while also suppressing adrenocorticotropic hormone secretion from the anterior pituitary (this lead to decrease libido etc,, effect of low T)
https://www.bluelight.org/xf/threads/managed-to-put-myself-into-opiate-wds-advice-needed.898547/ Restless legs syndrome https://www.bluelight.org/xf/threads/kratom-withdrawal-severity.903562/ increased sensitivity to physical touch and pain
opioid agonists increase and opioid antagonist decrease food intake https://www.nature.com/articles/s41467-018-03848-y the opiates Mu2 give you sense of contentment >>https://www.reddit.com/r/Psychonaut/comments/f6luui/willing_to_start_codeine_as_antidepressant_make/fi62ppp/?context=3 MOR μ2 https://en.wikipedia.org/wiki/Opioid_receptor euphoria

MOR μ3


NOR https://en.wikipedia.org/wiki/Nociceptin_receptor depression https://en.wikipedia.org/wiki/Opioid_receptor development of tolerance to μ-opioid agonists


NOR ORL1


ZOR https://en.wikipedia.org/wiki/Opioid_receptor tissue growth

NOP

https://en.wikipedia.org/wiki/Nociceptin_receptor treatments for depression and Parkinson's disease
ACKR3 In 2011, the Bohn lab noted antinociception against both chemically induced and inflammation-derived pain, and experiments indicated lack of opioid receptor inhibition, but were unable to define a particular target. A 2019 study by a cross-site Australian and U.S. group discovered through cultured neuronal networks that conolidine may inhibit the Ca v2.2 channel, a mechanism seen in molecules like conotoxin. The group was unable to rule out partial polypharmacology against other targets.[8]
It has been discovered to bind to novel opioid receptor ACKR3/CXCR7. By binding to that receptor, the endogenous opioid peptides (such as endorphins and enkephalins) cannot be trapped thus increasing availability of those peptides to their target sites.[9]
CXCR7
trace
amine
receptors
0.71 (dopamine) TAAR1 https://en.wikipedia.org/wiki/Dextroamphetamine decrease Serotonin, Noradrenaline, Dopamine, reuptake



TAAR2 not about depression
TAAR5
TAAR6
TAAR8
TAAR9
COMT

https://en.wikipedia.org/wiki/Catechol-O-methyltransferase convert catecholamine's to rubbish
https://en.wikipedia.org/wiki/Catechol-O-methyltransferase stop convert catecholamine's to rubbish https://en.wikipedia.org/wiki/Entacapone +levodopa
fos
ΔFosB happiness seeking behaviors (craving)
anti-craving effect
c-Fos https://en.wikipedia.org/wiki/C-Fos don't increase the chronic induction of ΔFosB
https://en.wikipedia.org/wiki/C-Fos increase the chronic induction of ΔFosB
adenosine
A1 https://en.wikipedia.org/wiki/Tianeptine anticonvulsant and analgesic
https://selfhacked.com/blog/caffeine-benefits/ https://en.wikipedia.org/wiki/Caffeine feel more energized and awake + heart-pounding effects
SAM-e appears to suppress the expression of adenosine receptor A2A >>https://www.longecity.org/forum/topic/106343-sam-e-appears-to-suppress-the-expression-of-adenosine-receptor-a2a/ A2A

https://en.wikipedia.org/wiki/Caffeine wakefulness-promoting effects, Antagonism of A2A receptors in the ventrolateral preoptic area reduces inhibitory GABA neurotransmission to the tuberomammillary nucleus, a histaminergic projection nucleus that activation-dependently promotes arousal
A2B provide protection from ischemia (lack of oxygen due to blocked blood supply) https://bmccancer.biomedcentral.com/articles/10.1186/s12885-015-1577-2 promotes progression of human oral cancer
anti-inflammatory https://pubmed.ncbi.nlm.nih.gov/10101031/ inhibits release of interleukins that is involved in the development of spatial memories
A3 https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=21 https://en.wikipedia.org/wiki/CP-532,903 https://en.wikipedia.org/wiki/Adenosine_A3_receptor anti-inflammatory


cAMP

stimulant

oxidants



decrease cell death due oxidative stress smooth skin (anti-aging effect)
PDE
1

https://en.wikipedia.org/wiki/PDE1 increase cAMP used in: Parkinson's disease, Alzheimer's disease, Epilepsy
1B
https://www.sciencedirect.com/science/article/abs/pii/S0167732221022091 D1 receptor potentiation
2
https://en.wikipedia.org/wiki/Phosphodiesterase_2 increase cAMP used in: improving memory
3
https://en.wikipedia.org/wiki/PDE3_inhibitor increase cAMP used in: acute heart failure and cardiogenic shock
4
https://www.longecity.org/forum/topic/104031-pde4is-as-antidepressant-who-has-tried-it/#entry868963 https://en.wikipedia.org/wiki/Phosphodiesterase-4_inhibitor increase cAMP used in: precognitive (including long-term memory-improving), wakefulness-promoting, neuroprotective, and anti-inflammatory effects
4B
https://chat.nootropicsrebirth.com/channel/c-rock-inhibition could be considered anti nootropic depending on dose
4D
https://chat.nootropicsrebirth.com/channel/c-rock-inhibition nausea
5
https://en.wikipedia.org/wiki/PDE5_inhibitor increase cAMP used in: erectile dysfunction
6
https://en.wikipedia.org/wiki/Cyclic_guanosine_monophosphate https://en.wikipedia.org/wiki/PDE6 loss of visual sensitivity but is unlikely to impair common visual tasks, except under conditions of reduced visibility when objects are already near visual threshold
7
https://en.wikipedia.org/wiki/Phosphodiesterase_inhibitor increase cAMP used in: anti-inflammatory and neuroprotective https://www.longecity.org/forum/topic/104975-s14-relief-from-anhedonia-and-induction-of-dopaminergic-neurogenesis/#entry872786 induction of dopaminergic neurogenesis
10 https://en.wikipedia.org/wiki/Papaverine motor and cognitive deficits and increased anxiety
https://en.wikipedia.org/wiki/Papaverine https://en.wikipedia.org/wiki/Tofisopam https://en.wikipedia.org/wiki/Phosphodiesterase_inhibitor increase cAMP used in: erectile dysfunction, treatment for schizophrenia
10A

https://www.sciencedirect.com/science/article/abs/pii/S0167732221022091 D2 receptor suppression
9
https://en.wikipedia.org/wiki/BAY_73-6691 increase cAMP used in: improve learning and memory
11 https://www.sciencedirect.com/science/article/pii/S1074552111004625 poorly understood, in part due to the lack of selective inhibitors
Oxytocin
Oxytocin https://en.wikipedia.org/wiki/Oxytocin love (mostly because androgen Neurotransmitter "Oxytocin" have wake biding affinity to Vasopressin 1A)


Vasopressin
1A https://en.wikipedia.org/wiki/Vasopressin_receptor_1A social recognition (mostly this is empathy of SSRIs + testosterone directly suppresses oxytocin in mice) https://en.wikipedia.org/wiki/Oxytocin Romantic attachment (physical and physiological) https://en.wikipedia.org/wiki/Oxytocin emotional talk + increase ability to trust others + increase generosity https://en.wikipedia.org/wiki/Oxytocin Oxytocin evokes feelings of contentment, reductions in anxiety, and feelings of calmness and security when you are with your friend
https://en.wikipedia.org/wiki/Vasopressin_receptor_1A reduced anxiety-like behavior https://en.wikipedia.org/wiki/Vasopressin_receptor_1A greatly impaired social recognition abilities https://en.wikipedia.org/wiki/Vasopressin_receptor_1A social isolation https://en.wikipedia.org/wiki/Vasopressin_receptor_1A deficits in circadian rhythms and olfaction
1B https://en.wikipedia.org/wiki/Arginine_vasopressin_receptor_1B aggression https://en.wikipedia.org/wiki/Vasopressin_receptor_1B ability to recognize recently investigated mice
https://en.wikipedia.org/wiki/Arginine_vasopressin_receptor_1B reduced social motivation or awareness
2 https://en.wikipedia.org/wiki/Vasopressin_receptor_2 antidiuretic


Orexin
OX1 https://en.wikipedia.org/wiki/Orexin happiness https://en.wikipedia.org/wiki/Orexin happiness seeking behaviors https://en.wikipedia.org/wiki/Orexin wakefulness + regulates energy expenditure + increase appetite + body temperature and locomotion
https://en.wikipedia.org/wiki/Orexin treatment of cocaine, opioid, and alcohol nicotine addiction https://en.wikipedia.org/wiki/Suvorexant Other concerns include thoughts of suicide
OX2

https://en.wikipedia.org/wiki/Orexin studies in rats using the dual orexin receptor antagonist TCS 1102 have not found similar effects in nicotine addiction https://en.wikipedia.org/wiki/JNJ-10397049 sleep-promoting effects and to attenuate the reinforcing effects of ethanol and mostly other drugs
P-glycoprotein

https://en.wikipedia.org/wiki/Quinidine https://en.wikipedia.org/wiki/Paliperidone prevent drugs from across BBB (involved in tolerance)
https://en.wikipedia.org/wiki/Quinidine cause some peripherally acting drugs to have central nervous system action too
estrogen main
ERα https://en.wikipedia.org/wiki/GTx-758 https://en.wikipedia.org/wiki/Estrogen_receptor_alpha induced increase in SHBG which lower free testosterone + upregulation of gonadal testosterone production due to reduced negative feedback by androgens on the hypothalamic–pituitary–gonadal axis https://en.wikipedia.org/wiki/Estrogen_receptor_alpha undersized testes, stimulate cell proliferation in breast tissue https://en.wikipedia.org/wiki/Estrogen_receptor_alpha maintenance of bone integrity https://en.wikipedia.org/wiki/GPER antidepressant-like effects


ERβ interacts with metabotropic glutamate receptor 1a (mGluR1a) >>https://www.jneurosci.org/content/35/38/13110 Erβ https://en.wikipedia.org/wiki/Estrogen_receptor_beta anti-proliferative in reproductive tissue https://en.wikipedia.org/wiki/GPER anxiolytic https://en.wikipedia.org/wiki/3%CE%B2-Androstanediol https://en.wikipedia.org/wiki/WAY-200070 antidepressant, anxiolytic, cognitive-enhancing, and stress-relieving https://en.wikipedia.org/wiki/3%CE%B2-Androstanediol up-regulates oxytocin receptors https://www.jneurosci.org/content/35/38/13110 increase sexual motivation
https://en.wikipedia.org/wiki/Estrogen_receptor_beta https://en.wikipedia.org/wiki/Erteberel cognitive impairment , and development of AD pathology https://en.wikipedia.org/wiki/Estrogen_receptor_beta Abnormalities in gene expression associated with ER-β have also been linked to autism spectrum disorder
GPER https://en.wikipedia.org/wiki/GPER GPER and ERβ play a modulator role in breast development, ERα is the main receptor responsible for estrogen-mediated breast tissue growth https://en.wikipedia.org/wiki/GPER anxiogenic https://en.wikipedia.org/wiki/GPER Lordosis to front


Estrogen-related receptor
ERRα

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=622&familyId=97&familyType=NHR ERRalpha KO mice:-reduced body weight, resistant to high-fat diet induced obesity
ERRβ
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=623&familyId=97&familyType=NHR ERRβ Null Mice: show severely impaired placental formation.
ERRγ https://omictools.com/993460020c8f1ee79455400ac90c13e2-protocol https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=624&familyId=97&familyType=NHR protect pre-menopausal women from age-related hearing loss


Membrane estrogen receptor
Gq-mER https://en.wikipedia.org/wiki/Membrane_estrogen_receptor no info
Erx
ER-X
Androgen receptor
AR https://en.wikipedia.org/wiki/Androgen_receptor have important role in prostate cancer


GPRC6A https://en.wikipedia.org/wiki/GPRC6A mediate rapid, non-genomic prostate cancer cell responses to testosterone https://en.wikipedia.org/wiki/Membrane_androgen_receptor increase skeletal muscle strength, indicating potential anabolic effects, implicated in the antigonadotropic effects of androgens
14nM(Kd)
Testosterone has high affinity for ZIP9 with a Kd of 14 nM and acts as an agonist of the receptor. >>https://en.wikipedia.org/wiki/Zinc_transporter_ZIP9 ZIP9 https://en.wikipedia.org/wiki/Membrane_androgen_receptor increase skeletal muscle strength, indicating potential anabolic effects, implicated in the antigonadotropic effects of androgens
progesterone receptor
PR-A https://en.wikipedia.org/wiki/Progesterone_receptor serve to antagonize the effects of PR-B
https://en.wikipedia.org/wiki/Progesterone_receptor delayed but otherwise normal mammary ductal development at puberty https://en.wikipedia.org/wiki/Progesterone_receptor impaired lobuloalveolar development of the mammary glands
PR-B https://en.wikipedia.org/wiki/Progesterone_receptor positive regulator of the effects of progesterone

PR-C


mPRγ Wikipedia no info
mPRδ
mPRα
mPRβ
mPRϵ
AdipoR1
AdipoR2
Glucocorticoid receptor
NR3C1 https://en.wikipedia.org/wiki/Glucocorticoid_receptor https://en.wikipedia.org/wiki/Mineralocorticoid LINKED TO PTSD
Mineralocorticoid

Cannabinoid
CB1 https://en.wikipedia.org/wiki/Yangonin anxiolytic https://www.bluelight.org/xf/threads/receptors-function-database.882003/post-14700487 "THC acts as a CB1 agonist. As a CB1 antagonist, THCV has been shown to reduce appetite in murine" >>https://en.wikipedia.org/wiki/Tetrahydrocannabivarin https://en.wikipedia.org/wiki/Cannabinoid increase appetite, novelty, appreciation for food, music, art, analgesic, decrease short-term memory


CB2 https://en.wikipedia.org/wiki/JWH-133 anti-inflammation https://en.wikipedia.org/wiki/JWH-133 preventing cognitive impairment and loss of neuronal markers https://en.wikipedia.org/wiki/JWH-133 anti-cancer properties

NAGly
(GPR18)		 https://en.wikipedia.org/wiki/NAGly_receptor anti-inflammatory https://en.wikipedia.org/wiki/Abnormal_cannabidiol without producing any psychoactive effects

GPR55 https://en.wikipedia.org/wiki/GPR55 altered blood pressure regulation
GPR119 https://en.wikipedia.org/wiki/GPR119 body weight loss by reduction in food intake


inhibits the production of the second messenger cAMP from ATP. >>https://en.wikipedia.org/wiki/Neuropeptide_Y_receptor Neuropeptide Y receptor
Y1

https://en.wikipedia.org/wiki/BIBP-3226 regulation of appetite, anxiety, BIBP-3226 has anxiogenic and anorectic effects
presynaptic autoreceptor limiting further neuropeptide Y release >>https://en.wikipedia.org/wiki/BIIE-0246 Y2
https://en.wikipedia.org/wiki/BIIE-0246 reducing alcohol consumption in addicted rats[6][7] and anxiolytic effects
Y4


Y5
https://en.wikipedia.org/wiki/Lu_AA-33810 anorectic, antidepressant and anxiolytic effects
peroxisome proliferator-activated receptor
PPAR-α https://examine.com/supplements/oleoylethanolamide/research/#Yl1DjJP-neurology_Yl1DjJP-miscellaneous-mechanisms feeling of satiety after meals


PPAR-delta https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor_delta changes the body's fuel preference from glucose to lipids.[19] https://en.wikipedia.org/wiki/GW501516 sport doping agent

PPAR-γ uprgulate SERT + increase production of serotonin (the result is antidepressant effect) https://www.sciencedirect.com/science/article/pii/S0306452221005479 upregulates GABARα2 https://www.sciencedirect.com/science/article/pii/S0306452221005479 impair motivation and associative learning https://www.sciencedirect.com/science/article/pii/S0306452221005479 some phychological effect of diet-induced obesity

Melanocortin
MC1R https://en.wikipedia.org/wiki/%CE%91-MSH https://en.wikipedia.org/wiki/Melanocortin_1_receptor hyperpigmentation primarily of the hair and skin
https://en.wikipedia.org/wiki/Melanocortin_1_receptor decrease sensitivity to pain
MC2R https://en.wikipedia.org/wiki/ACTH_receptor upregulates levels of cAMP by activating adenylyl cyclase


MC3R

https://en.wikipedia.org/wiki/Melanocortin_3_receptor increased fat mass despite decreased food intake
MC4R "treatment of erectile dysfunction" https://en.wikipedia.org/wiki/PF-00446687 "treatment of female sexual dysfunction and erectile dysfunction" https://en.wikipedia.org/wiki/PL-6983 "powerful potential treatments for both female and male sexual dysfunction, including hypoactive sexual desire disorder and erectile dysfunction" https://en.wikipedia.org/wiki/Melanocortin_4_receptor "THIQ stimulated sexual activity in rats" https://en.wikipedia.org/wiki/THIQ powerful treatments for female and male sexual dysfunction https://en.wikipedia.org/wiki/Melanocortin_4_receptor via activation of the central oxytocin system, have been found to promote pair bond
"MC4 receptor antagonists produce pronounced antidepressant- and anxiolytic-like effects in animal models of depression and anxiety" https://en.wikipedia.org/wiki/Melanocortin_4_receptor produce pronounced antidepressant- and anxiolytic-like effects "Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity" https://pubs.acs.org/doi/10.1021/jm058241a "MC4R mutations were reported to be associated with inherited human obesity" https://en.wikipedia.org/wiki/Melanocortin_4_receptor Obesity
MC5R

https://en.wikipedia.org/wiki/Melanocortin_5_receptor male mice decreases aggressive behavior, promotes defensive behavior and encourages other male mice to attack MC5R-deficient males through pheremonal signals https://en.wikipedia.org/wiki/Melanocortin_5_receptor decreased production of sebum
Thyroid hormones
T3 https://en.wikipedia.org/wiki/Liothyronine weight loss, tremor, headache, upset stomach, vomiting, diarrhea, stomach cramps
nervousness, irritability, insomnia, excessive sweating, increased appetite, fever, changes in menstrual cycle, sensitivity to heat


ZINC RECEPTOR
GPR39 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790399/ SSRIs upregulate this (involved in the antidepressant response)

Histone deacetylase
HDAC2

https://en.wikipedia.org/wiki/Histone_deacetylase_2 treatment for Parkinson's Disease https://en.wikipedia.org/wiki/Histone_deacetylase_2 prevented cognitive and behavioral impairments in mice with Alzheimer's Disease
HDAC1
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2658 ==>Tacedinaline https://www.frontiersin.org/articles/10.3389/fnins.2021.674745/full showed increased acetylation of histone marks H3K27ac and H3K18ac at the dopamine 2 receptor (D2R) gene (Drd2) promoter and increased expression of the Drd2 mRNA and D2R protein in the striatum
HDAC3

HDAC4 https://en.wikipedia.org/wiki/HDAC4 regulates bone and muscle development
HDAC5 https://en.wikipedia.org/wiki/Histone_deacetylase_5 involved in memory consolidation
HDAC6 https://en.wikipedia.org/wiki/HDAC6 Mutations in this gene have been associated to Alzheimer's disease
HDAC8



HDAC9

HDAC10 https://en.wikipedia.org/wiki/HDAC10 HDAC10 has been shown to interact with Histone deacetylase 2, and Nuclear receptor co-repressor 2
HDAC11 https://en.wikipedia.org/wiki/HDAC11 upregulation of HDAC11 expression has also been seen in various cancer cells
Sirtuin https://en.wikipedia.org/wiki/Sirtuin implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation ( nicotinamide inhibit this)
acetylation marks H3K27ac Author: ibtisam: H3K27ac is well recognized as a marker for active enhancers and a great indicator of enhancer activity https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-01957-w (promoter)


H3K18ac Author: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562857/#:~:text=Acetylation%20of%20histone%203%20at,%2C%20prostate%2C%20and%20thyroid%20cancer. plays an important role in driving progression of many types of cancer, including breast, colon, lung, hepatocellular, pancreatic, prostate, and thyroid cancer

COX
COX-1



COX-2
https://en.wikipedia.org/wiki/COX-2_inhibitor suppressing inflammatory neurodegenerative pathways in mental illness
Neurotensin
NTS1

https://en.wikipedia.org/wiki/SR-142948 blocked the effects of stimulant drugs including MDMA
NTS2

GHB receptor
GPR172A https://en.wikipedia.org/wiki/GHB_receptor https://en.wikipedia.org/wiki/NCS-382 https://en.wikipedia.org/wiki/3-Chloropropanoic_acid do not produce a sedative effect, instead causing a stimulant effect followed by convulsions at higher doses, thought to be mediated through increased Na+/K+ current and increased release of dopamine and glutamate


Angiotensin II
AT1 https://en.wikipedia.org/wiki/Angiotensin_II_receptor_type_1 https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=34&familyId=6&familyType=GPCR increase vasoconstriction, aldosterone synthesis and secretion, increased vasopressin secretion
https://en.wikipedia.org/wiki/Angiotensin_II_receptor_type_1 reduce fear memory recall
AT2 https://en.wikipedia.org/wiki/Angiotensin_II_receptor https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=35&familyId=6&familyType=GPCR inhibition of cell growth https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=35&familyId=6&familyType=GPCR Over expression of the AT2 receptor down-regulated the AT1 receptor https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=35&familyId=6&familyType=GPCR Decrease of dopamine synthesis


AT3 no info in the first 100 Google search result
AT4 https://www.ncbi.nlm.nih.gov/pubmed/20224888 https://en.wikipedia.org/wiki/Angiotensin_II_receptor induce release of oxytocin (anxiolytic effect) https://www.ncbi.nlm.nih.gov/pubmed/12591177 https://www.ncbi.nlm.nih.gov/pubmed/15549174 https://www.ncbi.nlm.nih.gov/pubmed/16343778 https://www.ncbi.nlm.nih.gov/pubmed/21719467 enhances learning and memory and cognition


vitamin D receptor
VDR https://medlineplus.gov/vitaminddeficiency.html increase calcium absorption
https://medlineplus.gov/vitaminddeficiency.html loss of bone density
https://www.frontiersin.org/articles/10.3389/fimmu.2013.00148/full https://www.lifeextension.com/magazine/2013/8/the-overlooked-importance-of-vitamin-d-receptors regulates the expression of more than 900 genes (cell growth and development, immune function, and metabolic control)
Melatonin
MT1

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=287 MT1 receptor knockout mice exhibit depression-like behaviour and reduced mobility in the forced swim test compared to wild-type mice.
MT2
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=288 MT2 receptor knockout mice do not exhibit luzindole-mediated antidepressant-like actions, as seen in wild-type mice.
GPR50 https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=107 Physiological function of GPR50 remains unclear, although studies implicate the receptor in energy homeostasis [12].
calcium
α2δ-1

https://en.wikipedia.org/wiki/Gabapentin anticonvulsant, analgesic, and anxiolytic effects (opiates and benzo-like effect)
Sodium
Nav1.2

https://en.wikipedia.org/wiki/Nav1.2 mutations in this gene have been linked to several seizure disorders and autism, infantile spasms bitemporal glucose hypometabolism , and bipolar disorder
Nav1.3
https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=580&familyId=82&familyType=IC anti-Neuropathic pain
Nav1.4
https://en.wikipedia.org/wiki/Nav1.4 Mutations in the gene are associated with hypokalemic periodic paralysis, hyperkalemic periodic paralysis, paramyotonia congenita, and potassium-aggravated myotonia
Nav1.5
https://en.wikipedia.org/wiki/Nav1.5 cardiac diseases is associated with mutations (Long QT syndrome type 3)
Nav1.8
https://en.wikipedia.org/wiki/Nav1.8 https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=585&familyId=82&familyType=IC treatment of chronic pain
Nav1.9
https://en.wikipedia.org/wiki/Nav1.9 pain relief https://en.wikipedia.org/wiki/Nav1.9 anti-inflammatory
Potassium channels
K2P2.1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093650/ anxiolytic and antidepressive effect


Kv7.1

https://en.wikipedia.org/wiki/KvLQT1 Mutations in the gene can lead to a defective protein and several forms of inherited arrhythmias as Long QT syndrome, Short QT syndrome, and Familial Atrial Fibrillation
Kv7.2
https://en.wikipedia.org/wiki/Retigabine https://en.wikipedia.org/wiki/KvLQT2 anticonvulsants
G protein-coupled receptor kinase
GRK6

https://www.cell.com/neuron/fulltext/S0896-6273(03)00192-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627303001922%3Fshowall%3Dtrue https://en.m.wikipedia.org/wiki/G_protein-coupled_receptor_kinase upregulate D2/D3 receptor https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1471-4159.2001.00268.x upregulate mu-opiates receptors
GRK2 https://pubmed.ncbi.nlm.nih.gov/8631993/ The agonist-dependent phosphorylation of the rat D1A receptor was substantially increased
https://en.wikipedia.org/wiki/Paroxetine https://en.wikipedia.org/wiki/G_protein-coupled_receptor_kinase_2 https://www.jbc.org/article/S0021-9258(20)72281-7/fulltext upregulate β2 adrenergic receptors https://www.uniprot.org/uniprot/P35372 https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1471-4159.2001.00268.x https://www.jbc.org/article/S0021-9258(20)72281-7/fulltext "Arrestin beta 2 is crucial for the development of tolerance to morphine and other opioids." https://en.wikipedia.org/wiki/Arrestin_beta_2 upregulate mu-opiates receptors
GRK3
https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1471-4159.2001.00268.x https://www.frontiersin.org/articles/10.3389/fphar.2014.00280/full upregulate mu-opiates receptors https://www.frontiersin.org/articles/10.3389/fphar.2014.00280/full upregulate KOR-opiates receptors
GRK5


completely searched in https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=695 Retinoid receptor
RAR-alpha 1

https://en.wikipedia.org/wiki/Retinoic_acid_receptor_alpha Knock-out mice studies showed that a deletion in one of the copies of the RARA gene did not create any observable defect, while deletion of both copies shoes symptoms similar to that of Vitamin A deficiency. This proved that all 3 subtypes of RARs work redundantly. https://www.sciencedirect.com/science/article/abs/pii/S0361923018308190 Ro41-5253 (1 mg/kg) treatment downregulated RARα protein expression in hypothalamic PVN and hypothalamus, and increased the protein levels of BDNF, PSD95, SYP and MAP2 in the hippocampus. We concluded that Ro41-5253 had antidepressant-like effects on CUMS rats by downregulating HPA axis hyperactivity and improving the hippocampal neuronal deficits https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24972/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473493/ as the absence of retinoid receptors results in a reduced expression of the DA D2 receptor/mutations for the acid retinoic receptors demonstrated in mice could reduce expression of D1 and D2 receptors and do impair dopamine signaling
RAR-alpha 2

RAR-alpha 3

RAR-beta https://en.wikipedia.org/wiki/Retinoic_acid_receptor_beta limits growth of many cell types by regulating gene expression mentioned by friend (alessandro) upregulate dopamine 2 receptors
https://en.wikipedia.org/wiki/Retinoic_acid_receptor_beta https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128494/ associated with cancer onset/progression
RAR-gamma https://en.wikipedia.org/wiki/Retinoic_acid_receptor_gamma shown to interact with NCOR1 Depression, Mood changes, Suicidal ideation https://en.wikipedia.org/wiki/Alitretinoin https://en.wikipedia.org/wiki/Retinoid_X_receptor anti-cancer


RXR https://en.wikipedia.org/wiki/Bexarotene downregulation of thyroid stimulating hormone https://pubmed.ncbi.nlm.nih.gov/24434091/ significant increase in cholesterol levels and a decrease in total thyroxine levels

Tissue Distribution Click here for help:Liver, lung, muscle, kidney, epidermis, intestine, skin RXR-alpha https://en.wikipedia.org/wiki/Retinoid_X_receptor_alpha regulating their transcription (unknown what it is)
https://en.wikipedia.org/wiki/Retinoid_X_receptor RXR heterodimer in the absence of ligand is bound to hormone response elements complexed with corepressor protein. Binding of agonist ligands to RXR results in dissociation of corepressor and recruitment of coactivator protein, which, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

RXR-beta https://en.wikipedia.org/wiki/Retinoid_X_receptor_beta involved in mediating the effects of retinoic acid (RA). This increasing both DNA binding and transcriptional function on their respective response elements https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=611&familyId=92&familyType=NHR Induction of apoptosis (associated to RARa activation)

RXR-gamma https://en.wikipedia.org/wiki/Retinoid_X_receptor_gamma the antiproliferative effects of retinoic acid (RA). https://www.selleckchem.com/retinoid-receptor.html confirmed by by friend (alessandro): 40% of the D2 receptors are transcribed by the RARb-RXRy heterodimer Adapalene (CD-271) is a dual RAR and RXR agonist, used in the treatment of acne (which make sure that rxr is upregulate ht1a presynpatic receptors and dopamine 2) very strong acne treatment https://journals.physiology.org/doi/full/10.1152/ajpendo.00313.2001 https://en.wikipedia.org/wiki/Retinoid_X_receptor_gamma suppression of thyroid function
https://pubmed.ncbi.nlm.nih.gov/20620876/ ablation of Rxrgamma in mice leads to depressive-like behaviors including increased despair and anhedonia, which were accompanied by reduced expression of dopamine D2 receptor in the shell of nucleus accumbens (NAc) and altered serotonin signaling (proberly increase singling of serotonin)
Nuclear receptor NCOR1 https://en.wikipedia.org/wiki/Nuclear_receptor_co-repressor_2 https://en.wikipedia.org/wiki/Nuclear_receptor_co-repressor_1 assists nuclear receptors in the down regulation of target gene expression (unknown what it is)
https://en.wikipedia.org/wiki/Nuclear_receptor_co-repressor_1 Loss of function of this protein significantly increases the strength and power of mouse muscles
NCOR2


Neurokinin
TACR1 https://en.wikipedia.org/wiki/Tachykinin_receptor_1 https://en.wikipedia.org/wiki/Vestipitant https://en.wikipedia.org/wiki/L-733,060 has been associated with the transmission of stress signals and pain
https://en.wikipedia.org/wiki/Aprepitant 99% human receptor occupancy might be required for consistent psycho-pharmacological or other therapeutic effects https://en.wikipedia.org/wiki/Aprepitant https://en.wikipedia.org/wiki/Casopitant https://en.wikipedia.org/wiki/Maropitant prevent chemotherapy-induced nausea and vomiting https://en.wikipedia.org/wiki/Maropitant anti-pain
TACR2

https://en.wikipedia.org/wiki/Saredutant https://en.wikipedia.org/wiki/GR-159897 antidepressant and anxiolytic https://en.wikipedia.org/wiki/GR-159897 treatment of asthma
TACR3
https://en.wikipedia.org/wiki/Fezolinetant https://en.wikipedia.org/wiki/Pavinetant dose-dependently suppress luteinizing hormone (LH) secretion, though not that of follicle-stimulating hormone (FSH), and consequently to dose-dependently decrease estradiol and progesterone levels in women and testosterone levels in men
orphan receptors
GPR35 https://en.wikipedia.org/wiki/Pamoic_acid https://en.wikipedia.org/wiki/Lodoxamide activates ERK and beta-arrestin2, and causes antinociceptive activity (increase pain sensitivity) https://en.wikipedia.org/wiki/Lodoxamide https://en.wikipedia.org/wiki/GPR35 development of stomach cancer https://en.wikipedia.org/wiki/Lodoxamide inflammatory processes


transient receptor potential channel
TRPA1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567430/ sensor of noxious cold https://en.m.wikipedia.org/wiki/TRPV1 "Desensitization of TRPV1 is thought to underlie the paradoxical analgesic effect of capsaicin."
" a recent report, it was found that tonically active TRPV1 channels are present in the viscera and keep an ongoing suppressive effect on body temperature"
 https://en.m.wikipedia.org/wiki/TRPV1 "TRPV1 was shown to have protective effect in neurologic disorders such as vascular dementia" link to chilli caused me better blood follow in brain
https://en.m.wikipedia.org/wiki/TRPV1 AMG-517, a highly selective TRPV1 antagonist was dropped out of clinical trials due to the causation of hyperthermia
https://en.m.wikipedia.org/wiki/TRPV1 Eight percent capsaicin patches have recently become available for clinical use, with supporting evidence demonstrating that a 30-minute treatment can provide up to 3 months analgesia by causing regression of TRPV1-containing neurons in the skin, Currently, these treatments must be re-administered on a regular (albeit infrequent) schedule in order to maintain their analgesic effects.

 https://en.m.wikipedia.org/wiki/TRPV1 AM404 also serves as a potent TRPV1 agonist, cannabinoid cannabidiol also shows "either direct or indirect activation" of TRPV1 receptors https://en.m.wikipedia.org/wiki/TRPV1 proposed as a target for treatment not only of pain but also for other conditions such as anxiety, TRPV1 appears to mediate long-term synaptic depression (LTD) in the hippocampus


TRPV3

https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=509 impaired thermosensation, display a wavy hair coat and curly whiskers and have dry and scaly skin.
TRPC6 >>https://en.wikipedia.org/wiki/Adhyperforin inhibiting the reuptake of various neurotransmitters including serotonin, norepinephrine, dopamine, GABA, and glutamate


TRPM8 https://en.wikipedia.org/wiki/AMG-333 responsible for the sensation of cold https://en.wikipedia.org/wiki/TRPM8 increases the sensation of cold pain, also known as cold hyperalgesia
https://en.wikipedia.org/wiki/TRPM8 improve cold tolerance
Translocator protein (peripheral benzodiazepine receptor)
TSPO https://en.wikipedia.org/wiki/DAA-1097 https://en.wikipedia.org/wiki/DAA-1106 https://en.wikipedia.org/wiki/Emapunil anxiolytic https://en.wikipedia.org/wiki/Emapunil anti-panic effects


https://en.wikipedia.org/wiki/Emapunil regulation of steroidogenesis, particularly the production of neuroactive steroids such as allopregnanolone in the brain
insulin receptors
metabolic insulin receptor B (INSRB)



insulin receptor A (INSRA)

insulin-like growth factor type 1 receptor (IGF1R)

insulin-like growth factor type 2 receptor IGF-II

Glycine
GLRA1

https://en.wikipedia.org/wiki/Glycine_receptor,_alpha_1 hyperekplexia
GLRA2


GLRA3
https://pubmed.ncbi.nlm.nih.gov/15131310/ (KO) lacked the inhibition of glycinergic neurotransmission by prostaglandin E2 seen in wildtype mice but also showed a reduction in pain sensitization induced by spinal prostaglandin E2 injection or peripheral inflammation
GLRA4 https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=73 https://en.wikipedia.org/wiki/GLRA4 pseudogene in humans
GLRB



Purinergic receptor
P2RX1



P2RX2

P2RX3

P2RX4

P2RX5

P2RX6

P2RX7

NPS suppresses anxiety and appetite, induces wakefulness and hyperactivity, including hyper-sexuality, and plays a significant role in the extinction of conditioned fear https://en.wikipedia.org/wiki/Neuropeptide_S Neuropeptide S receptor
NPSR https://en.wikipedia.org/wiki/Neuropeptide_S_receptor need less sleep time than normal ones. And resistant to memory impairment caused by lack of sleep. https://en.wikipedia.org/wiki/Neuropeptide_S_receptor promotes arousal and anxiolytic-like effects




https://en.wikipedia.org/wiki/DLG4 PSD-95



glucose
GLUT3





substance p

anxiolaytic, works if you have pain, by inhibiting it (that's it!)
Glycogen_synthase_kinase
GSK3A

https://en.wikipedia.org/wiki/GSK3A Twenty one tests were carried out on mutant mice but no significant abnormalities were observed
GSK3B https://en.wikipedia.org/wiki/Glycogen_synthase_kinase-3_beta bipolar disorder https://en.wikipedia.org/wiki/Glycogen_synthase_kinase-3_beta inactivating agent of glycogen synthase
https://en.wikipedia.org/wiki/Lithium_(medication) Lithium inhibit it
M-phase inducer phosphatase
CDC25C https://en.wikipedia.org/wiki/CDC25C This gene is highly conserved during evolution
cytokine Interleukin IL-2



IL-1B https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560336/ accumulating evidence has indicated that IL-1β also adversely affects cognitive function (learning and memory) https://www.sciencedirect.com/science/article/abs/pii/S0889159103001405 High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β https://www.frontiersin.org/articles/10.3389/fnbeh.2017.00202/full https://journals.sagepub.com/doi/10.1177/2398212820979802 may have a beneficial, temporary effect on learning and memory in young mice (dose depandant)

https://pubmed.ncbi.nlm.nih.gov/21113196/ mediating inflammation and orchestrating the physiological and behavioral adjustments that occur during sickness https://www.sciencedirect.com/science/article/abs/pii/S0166432819300269 Memory consolidation impairment induced by Interleukin-1β (contextual memory) and a reduction in the total density of CA1 hippocampal dendritic spines

IL-1


low-density lipoprotein
LDL-R



carrier protein fatty acids aP2/FABP4

FABP4 effect on cognition https://chat.openai.com/chat when FABP4 was genetically deleted in mice, the animals exhibited improved spatial memory and increased neurogenesis (the production of new neurons)

FABP4 was overexpressed ,the mice showed impaired spatial memory and reduced neurogenesis.

FABP4 levels in the blood were negatively correlated with cognitive function in older adults. Specifically, higher levels of FABP4 were associated with poorer performance on tests of executive function and processing speed.
Prostaglandin receptor Prostaglandin E2 receptor EP1



kidney, kidney tubule, gastric mucosa, spleen, metanephric glomerulus, body of stomach, renal medulla, stromal cell of endometrium, fundus, upper lobe of left lung
EP2

monocyte, blood, bone marrow, bone marrow cells, canal of the cervix, gastric mucosa, cancellous bone, appendix, spleen, Achilles tendon
EP3

kidney tubule, kidney, renal medulla, myometrium, vena cava, adipose tissue, abdominal fat, subcutaneous adipose tissue, smooth muscle tissue, lower lobe of lung
EP4

palpebral conjunctiva, jejunal mucosa, glomerulus, metanephric glomerulus, bronchial epithelial cell, visceral pleura, synovial joint, germinal epithelium, parietal pleura, superficial temporal artery
Prostaglandin DP DP1

rectum, parietal pleura, germinal epithelium, trigeminal ganglion, blood, spleen, visceral pleura, Achilles tendon, right coronary artery, lymph node
DP2

islet of Langerhans, body of stomach, monocyte, left ventricle, rectum, putamen, gastrocnemius muscle, prefrontal cortex, caudate nucleus, amygdala
Prostaglandin F2α, Prostacyclin I2 receptor, Thromboxane A2 receptor FP

Achilles tendon, gastric mucosa, tibial nerve, bronchial epithelial cell, synovial joint, smooth muscle tissue, stromal cell of endometrium, urethra, gallbladder, right coronary artery
IP

ascending aorta, right coronary artery, left coronary artery, upper lobe of left lung, monocyte, right lung, pericardium, vena cava, right lobe of thyroid gland, left lobe of thyroid gland
TP

olfactory bulb, popliteal artery, right coronary artery, ascending aorta, vena cava, left coronary artery, saphenous vein, pancreatic ductal cell, glomerulus, metanephric glomerulus

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