using substance vs gene editing to improve health

After researching in various receptors tolerance I think

tolerance in biology = buttolneck in electronics

The same phenomena

Mean gene editing will not prevent tolerance

So the only almosly left benefits of gene editing is "do once stay for ever" which double-edged sword, you need to know how to decrease gene expressions of proteins with ability to reverse that if something bad happen, without being die in the attempt

You can get what you want right now with substance as long as you are in them, i know when I do editing attempt , not hasty or anything